2349184
doi
10.5281/zenodo.2349184
oai:zenodo.org:2349184
user-iajpr
NOVEL PYRIMIDINE SCHIFF BASES: SYNTHESIS AND PHARMACOLOGICAL SCREENING
C. Mallikarjunaswamy*1, V. Lakshmi Ranganatha2, L. Mallesha1, D.G. Bhadregowda3
1JSS College of Arts, Commerce and Science, Ooty Road, Mysore-25, India. 2The National Institute of Engineering, Manandavadi Road, Mysuru – 08. 3Yuvaraja's College, University of Mysore, Mysore-5, India.
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Schiff Base, Aldehyde, Antimicrobial Activity, Antioxidant Activity, Anti-Inflammatory.
<p>Schiff bases are aldehydelike compounds in which an imine group replaces the carbonyl group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This study represents the synthesis of a new series of (E) -N-benzylidene-5-bromo-2-chloropyrimidin-4-amine derivatives (6a-l). The newly synthesized compounds were characterized by different spectral studies. All these new compounds screened for their anti-inflammatory, antimicrobial and in vitro antioxidant activities. Structure–activity relationship analysis demonstrates that hydroxyl groups on the aromatic ring contribute critically to the antioxidant activity. Compounds 6k, 6j, 6dand 6e showed significant radical scavenging and compounds 6d, 6e and 6f showed good antimicrobial and anti-inflammatory activities.</p>
Zenodo
2017-01-31
info:eu-repo/semantics/article
2349183
user-iajpr
1579542098.022589
848659
md5:f88198521719df467a85d080047b242b
https://zenodo.org/records/2349184/files/3.pdf
public
10.5281/zenodo.2349183
isVersionOf
doi