10.5281/zenodo.2222287
https://zenodo.org/records/2222287
oai:zenodo.org:2222287
Küpers, LK
LK
Küpers
0000-0001-9850-5215
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
et al.
et al.
Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Zenodo
2018
DNA methylation
EWAS
epigenome-wide association study
meta-analysis
epigenetic epidemiology
birthweight
birth weight
DOHAD
PACE consortium
Pregnancy And Childhood Epigenetics
2018-12-12
eng
10.5281/zenodo.2222286
1
Creative Commons Attribution 4.0 International
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni<1.06x10-7).