Preview

1 - HTT clones
- .DS_Store
  
  6.1 kB
- HTT_clone_information.xlsx
  
  99.1 kB
- pBMDEL.FASTA
  
  8.8 kB
2 - Expression and purification of HTT and HTT-HAP40 Q23
- Large scale expression and purification of full-length huntingtin Q19 and Q23 from baculoviral expression system production in sf9 insect cells ΓÇô 2018-07-06.pdf
  
  1.3 MB
- Large scale expression and purification of full-length huntingtin Q23 with HAP40 in BVES sf9 insect cells ΓÇô 20180528.pdf
  
  1.1 MB
- Purification of HTT and HTT-HAP40.docx
  
  12.6 kB
- Purification of HTT and HTT-HAP40.pdf
  
  1.6 MB
- Purification of HTT and HTT.docx
  
  12.6 kB
3 - Mass spectometry analysis of HTT samples
- .DS_Store
  
  14.3 kB
- HTT_1-3144_Q23_EXPI293F
  - Htt Q23 HEK solution_PEAKS PTM_4_313 mods
    - DB search psm.csv
      
      603.7 kB
    - PSM ions.csv
      
      11.2 MB
    - de novo only peptides.csv
      
      71.4 kB
    - peptide.csv
      
      166.3 kB
    - protein-peptides.csv
      
      219.3 kB
    - proteins.csv
      
      50.0 kB
    - proteins.fasta
      
      710.9 kB
  - Htt band Q23 HEK_PEAKS PTM_7
    - DB search psm.csv
      
      307.8 kB
    - PSM ions.csv
      
      5.9 MB
    - de novo only peptides.csv
      
      127.1 kB
    - peptide.csv
      
      85.4 kB
    - protein-peptides.csv
      
      74.7 kB
    - proteins.csv
      
      14.2 kB
    - proteins.fasta
      
      180.5 kB
  - protein-peptides_allHEKQ23.xlsx
    
    1.1 MB
- HTT_1-3144_Q23_Sf9
  - .DS_Store
    
    18.4 kB
  - Htt - MtALP_PEAKS PTM_14
    - DB search psm.csv
      
      167.9 kB
    - PSM ions.csv
      
      1.7 MB
    - de novo only peptides.csv
      
      92.1 kB
    - peptide.csv
      
      109.9 kB
    - protein-peptides_MtALP_PEAKS_PTM_14.csv
      
      37.1 kB
    - proteins.csv
      
      2.9 kB
    - proteins.fasta
      
      61.6 kB
  - Htt - WtALP_PEAKS PTM_21
    - DB search psm.csv
      
      271.1 kB
    - PSM ions.csv
      
      2.9 MB
    - de novo only peptides.csv
      
      86.8 kB
    - peptide.csv
      
      130.5 kB
    - protein-peptides.csv
      
      54.6 kB
    - proteins.csv
      
      2.3 kB
    - proteins.fasta
      
      30.3 kB
  - Htt - trypsin MtALP WtALP_lowered p value cutoff
    - DB search psm.csv
      
      354.3 kB
    - PSM ions.csv
      
      6.3 MB
    - de novo only peptides.csv
      
      279.8 kB
    - peptide.csv
      
      146.1 kB
    - protein-peptides_MtALP_WtALP_lowered_p value cutoff.csv
      
      172.2 kB
    - proteins.csv
      
      498 Bytes
    - proteins.fasta
      
      3.3 kB
  - Htt - trypsin MtALP WtALP_together
    - DB search psm.csv
      
      584.4 kB
    - PSM ions.csv
      
      7.9 MB
    - de novo only peptides.csv
      
      299.7 kB
    - peptide.csv
      
      345.3 kB
    - protein-peptides.csv
      
      168.9 kB
    - proteins.csv
      
      7.1 kB
    - proteins.fasta
      
      123.7 kB
  - Htt lysarg trypsin 4hr_18hr_PTM 14_313 mods
    - DB search psm.csv
      
      1.3 MB
    - PSM ions.csv
      
      24.0 MB
    - de novo only peptides.csv
      
      343.3 kB
    - peptide.csv
      
      272.1 kB
    - protein-peptides.csv
      
      270.2 kB
    - proteins.csv
      
      37.8 kB
    - proteins.fasta
      
      387.5 kB
  - Htt lysarg trypsin 4hr_18hr_searched together Phospho
    - DB search psm.csv
      
      1.8 MB
    - PSM ions.csv
      
      30.4 MB
    - de novo only peptides.csv
      
      273.4 kB
    - peptide.csv
      
      665.3 kB
    - protein-peptides.csv
      
      324.7 kB
    - proteins.csv
      
      53.0 kB
    - proteins.fasta
      
      535.5 kB
  - Htt pepsin reanalysis_all files
    - DB search psm.csv
      
      489.1 kB
    - PSM ions.csv
      
      6.1 MB
    - de novo only peptides.csv
      
      1.1 MB
    - peptide.csv
      
      93.6 kB
    - protein-peptides.csv
      
      105.5 kB
    - proteins.csv
      
      611 Bytes
  - Q23 sf9_all enzymes
    - DB search psm.csv
      
      2.1 MB
    - HttQ23 sf9 all enzymes Htt only.png
      
      1.1 MB
    - PSM ions.csv
      
      37.2 MB
    - de novo only peptides.csv
      
      729.1 kB
    - peptide.csv
      
      499.9 kB
    - protein-peptides.csv
      
      550.4 kB
    - protein-peptides_allQ23.xlsx
      
      818.4 kB
    - protein-peptides_allQ23_sf9.xlsx
      
      867.4 kB
    - protein-peptides_all_Q23.csv
      
      556.2 kB
    - proteins.csv
      
      1.3 kB
    - proteins.fasta
      
      3.3 kB
  - protein-peptides_MtALP_PEAKS_PTM_14.csv
    
    37.1 kB
  - protein-peptides_MtALP_WtALP_lowered_p value cutoff.csv
    
    172.2 kB
- NetPhos_HTT.rtfd
  - TXT.rtf
    
    522.4 kB
  - m_logo.gif
    
    1.7 kB
  - netphos-3.1b.Sequence.gif
    
    18.8 kB
- PNG_Spectra_files
  - .DS_Store
    
    6.1 kB
  - Htt-HEK-solution-tryp.ai
    
    3.7 MB
  - Htt-HEK-solution-tryp_AALPS-1.png
    
    95.9 kB
  - Htt-HEK-solution-tryp_AALPS-2.png
    
    96.1 kB
  - Htt-HEK-solution-tryp_EKE.png
    
    96.1 kB
  - Htt-HEK-solution-tryp_EPGEQ-1.png
    
    105.4 kB
  - Htt-HEK-solution-tryp_HSLsSTK-1.png
    
    98.6 kB
  - Htt-HEK-solution-tryp_PQF--K2996me-1.png
    
    254.3 kB
  - Htt-HEK-solution-tryp_RHSL-1.png
    
    96.9 kB
  - Htt-HEK-solution-tryp_RHSL-2.ai
    
    218.7 kB
  - Htt-HEK-solution-tryp_RHSL-2.png
    
    96.5 kB
  - Htt-HEK-solution-tryp_RHSLSStK-1.png
    
    85.6 kB
  - Htt-HEK-solution-tryp_SGS-1.png
    
    116.6 kB
  - Htt-HEK-solution-tryp_SGS-2.png
    
    116.8 kB
  - Htt-HEK-solution-tryp_SGS-3.png
    
    108.6 kB
  - Htt-HEK-solution-tryp_SGS-4.png
    
    120.1 kB
  - Htt-HEK-solution-tryp_SGS-5.png
    
    104.9 kB
  - Htt-HEK-solution-tryp_SGS-6.png
    
    105.5 kB
  - Htt-HEK-solution-tryp_SGS-7.png
    
    117.6 kB
  - Htt-HEK-solution-tryp_SGS-8.png
    
    92.6 kB
  - Htt-HEK-solution-tryp_SGS-9.png
    
    101.5 kB
  - Htt-HEK-solution-tryp_SSHLPSR-1.png
    
    102.7 kB
  - Htt-Q23-Sf9 - 2.ai
    
    10.3 MB
  - Htt-Q23-Sf9.ai
    
    6.6 MB
  - Htt-Sf9 all_TPPPELLQTLt.png
    
    96.8 kB
  - Htt-Sf9-all-RHSLSStK.png
    
    95.0 kB
  - HttQ23-Sf9-soln-pepsin_pH1_ASVPLS-1.png
    
    87.6 kB
  - HttQ23-Sf9-soln-pepsin_pH1_ASVPLS-2.png
    
    76.9 kB
  - HttQ23-Sf9-soln-pepsin_pH1_DGDGHVSL-1.png
    
    76.8 kB
  - HttQ23-Sf9-soln-pepsin_pH1_IAGGGS-1.png
    
    86.2 kB
  - HttQ23-Sf9-soln-pepsin_pH1_PLLPQPQ-1.png
    
    97.4 kB
  - HttQ23-Sf9-soln-pepsin_pH1_PLLPQPQ-2.png
    
    108.1 kB
  - HttQ23-Sf9-soln-tryp4hr_S95_T97_1.png
    
    316.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_ALALS719_1.png
    
    93.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_ALALS719_2.png
    
    80.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_ALALSC_me-1.png
    
    80.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_CRPYLVNLLPCLT216_1.png
    
    86.8 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_CRmePYLVN-1.png
    
    73.5 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_CWT2112RSDSA_1.png
    
    76.6 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_DTSLKGS337_1.png
    
    100.1 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_GQkS2164ALFEAAR_1.png
    
    75.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_GYNLL_S997_1.png
    
    92.8 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_IIQLcDGIMAS1532_1.png
    
    83.3 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_IQS1959_1.png
    
    82.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_KVS1398TQL_1.png
    
    85.7 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_LLSPQMS1874_1.png
    
    87.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_LLSPQMS1876_1.png
    
    103.1 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_PeaksPTM14_T2112Rme2-1.png
    
    405.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_PeaksPTM14_WT2112-1.png
    
    116.6 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_PeaksPTM14_WT2112-2.png
    
    420.4 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1398_1.png
    
    80.8 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1511_1.png
    
    92.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1513KQIIGIPK_1.png
    
    65.3 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1709_1.png
    
    92.2 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1959-2.png
    
    90.3 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S337_1.png
    
    101.5 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S785_1.png
    
    95.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S785_2.png
    
    90.4 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S819_2.png
    
    93.5 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S822_1.png
    
    87.8 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S997_1.png
    
    86.3 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_SIIRme1-1.png
    
    102.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T1403NLTSVT_1.png
    
    100.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T1403_1.png
    
    102.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T1406_1.png
    
    89.6 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T269_S273-1.png
    
    91.1 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T900_1.png
    
    79.9 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_TLTGNT801FS803_2.png
    
    78.6 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_TLTGNT801_1.png
    
    88.5 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_YHS1511kQIIGIPK_1.png
    
    93.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017_cWtrSD-1.png
    
    88.0 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017rerun4hrMar18_S1874_1.png
    
    88.3 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017rerun4hrMar18_S411_1.png
    
    125.5 kB
  - HttQ23-Sf9-soln-tryp_lysarg_Oct2017rerun4hrMar18_S621_1.png
    
    104.0 kB
  - HttQ23-Sf9-solution-tryp_AALPS-1.png
    
    118.1 kB
  - HttQ23-Sf9-solution-tryp_AALPS-2.png
    
    115.8 kB
  - HttQ23-Sf9-solution-tryp_AALPS-3.png
    
    105.3 kB
  - HttQ23-Sf9-solution-tryp_ASAPKSLR-1.png
    
    81.9 kB
  - HttQ23-Sf9-solution-tryp_EKE-1.png
    
    105.8 kB
  - HttQ23-Sf9-solution-tryp_EPGEQA-1.png
    
    127.8 kB
  - HttQ23-Sf9-solution-tryp_HSLSSTK-1.png
    
    108.1 kB
  - HttQ23-Sf9-solution-tryp_IAGGG-1.png
    
    115.7 kB
  - HttQ23-Sf9-solution-tryp_RHSLSSTK-1.png
    
    98.2 kB
  - HttQ23-Sf9-solution-tryp_SGS-1.png
    
    128.3 kB
  - HttQ23-Sf9-solution-tryp_SGS-2.png
    
    117.1 kB
  - HttQ23-Sf9-solution-tryp_SGS-3.png
    
    120.4 kB
  - HttQ23-Sf9-solution-tryp_SGS-4.png
    
    118.3 kB
  - HttQ23-Sf9-solution-tryp_SGS-5.png
    
    111.3 kB
  - HttQ23-Sf9-solution-tryp_VGALHme-1.png
    
    104.2 kB
  - HttQ23-hek-gel band-tryp_H2786me-3.png
    
    268.4 kB
  - HttQ23-hek-gel band-tryp_S1106-1.png
    
    290.0 kB
  - HttQ23-hek-gel band-tryp_S2690_1.png
    
    319.4 kB
  - HttQ23-hek-soln-tryp_H2774me.png
    
    314.1 kB
  - HttQ23-hek-soln-tryp_H2786me-2.png
    
    342.8 kB
  - HttQ23-hek-soln-tryp_K2998me.png
    
    292.1 kB
  - HttQ23-hek-soln-tryp_R2779me1_1.png
    
    354.5 kB
  - HttQ23-hek-soln-tryp_R2781me-1.png
    
    425.8 kB
  - HttQ23-hek-soln-tryp_T1306ub_1.png
    
    289.6 kB
  - Q23 Sf9 Tryp solution 4hr rerun_T3055-1.png
    
    289.9 kB
  - Q23 Sf9 all data_H2796me-1.png
    
    358.0 kB
  - Q23 Sf9 pepsin_S2029-1.png
    
    298.0 kB
  - SGSphospho1.png
    
    103.2 kB
  - Sf9 lysarg_tryp_T271_S275.png
    
    339.0 kB
  - SmeITYGTGSMTGILGY.png
    
    113.9 kB
- Sequence_coverage
  - .DS_Store
    
    6.1 kB
  - Q23 HEK293 band.png
    
    1.1 MB
  - Q23 HEK293.png
    
    1.1 MB
  - Sf9 all enzymes.png
    
    1.1 MB
  - Sf9 lysarg and trypsin.png
    
    1.1 MB
4 - SEC-MALS and DSLS analysis of HTT and HTT-HAP40
- DSLS_HTT_Q19234254_20181005.pzfx
  
  29.2 kB
- HTT_DSLS_20180503.xlsx
  
  399.9 kB
- HTT_HAP40_DSLS.pzfx
  
  20.1 kB
- HTT_HAP40_DSLS_20181013.xlsx
  
  84.5 kB
- MALS_Raw_data_summary_20181130.xlsx
  
  902.2 kB
- MALS_summary.pzfx
  
  607.2 kB
5 - SAXS data and molecular modelling
- .DS_Store
  
  10.2 kB
- SAXS
  - Buffer_Shunt13144buf1_00058.avg
    
    18.9 kB
  - Buffer_Shunt13144buf_00052.avg
    
    18.9 kB
  - Buffer_Shunthapbuf_00064.avg
    
    18.9 kB
  - HTT_05mgml_Shunt13144a05_00053.avg
    
    18.9 kB
  - HTT_05mgml_Shunt13144a05a_00061.avg
    
    18.9 kB
  - HTT_1mgml_Shunt13144a10_00054.avg
    
    18.9 kB
  - HTT_1mgml_Shunt13144a1a_00060.avg
    
    18.9 kB
  - HTT_2mgml_Shunt13144a20_00055.avg
    
    18.8 kB
  - HTT_2mgml_Shunt13144a2a_00059.avg
    
    18.9 kB
  - HTT_4mgml_Shunt13144a40_00057.avg
    
    18.8 kB
  - HTT_HAP40_05mgml_Shunthap05_00070.avg
    
    18.7 kB
  - HTT_HAP40_05mgml_Shunthap05a_00068.avg
    
    18.9 kB
  - HTT_HAP40_1mgml_Shunthap1_00066.avg
    
    18.7 kB
  - HTT_HAP40_1mgml_Shunthap1a_00067.avg
    
    18.6 kB
  - HTT_HAP40_2mgml_Shunthap2all_00065.avg
    
    18.8 kB
  - HTT_HAP40_2mgml_Shunthap2sel_00065.avg
    
    18.6 kB
  - hulison062018.pxp
    
    358.7 kB
- SES_ensemble
  - hthpses2_5.list
    
    155 Bytes
  - test10_trj_17w.pdb
    
    1.5 MB
  - test10_trj_95w.pdb
    
    1.5 MB
  - test1_trj_159w.pdb
    
    1.5 MB
  - test1_trj_184w.pdb
    
    1.5 MB
  - test3_trj_200w.pdb
    
    1.5 MB
- WAXS
  - Buffer_Whunt13144buf1_00058.avg
    
    18.2 kB
  - Buffer_Whunt13144buf_00052.avg
    
    18.1 kB
  - Buffer_Whunthapbuf_00064.avg
    
    18.1 kB
  - HTT_05mgml_Whunt13144a05_00053.avg
    
    18.1 kB
  - HTT_05mgml_Whunt13144a05a_00061.avg
    
    18.2 kB
  - HTT_1mgml_Whunt13144a10_00054.avg
    
    18.1 kB
  - HTT_1mgml_Whunt13144a1a_00060.avg
    
    18.1 kB
  - HTT_2mgml_Whunt13144a20_00055.avg
    
    18.0 kB
  - HTT_2mgml_Whunt13144a2a_00059.avg
    
    18.1 kB
  - HTT_4mgml_Whunt13144a40_00057.avg
    
    18.0 kB
  - HTT_HAP40_05mgml_Whunthap05_00070.avg
    
    17.9 kB
  - HTT_HAP40_05mgml_Whunthap05a_00068.avg
    
    18.1 kB
  - HTT_HAP40_1mgml_Whunthap1_00066.avg
    
    17.9 kB
  - HTT_HAP40_1mgml_Whunthap1a_00067.avg
    
    17.8 kB
  - HTT_HAP40_2mgml_Whunthap2_00065.avg
    
    17.8 kB
6 - Manuscript
- Harding_Huntingtin_manuscript_20181210.docx
  
  8.2 MB
- Harding_Huntingtin_manuscript_20181210.pdf
  
  8.4 MB
__MACOSX
- 1 - HTT clones
  - ._.DS_Store
    
    120 Bytes
  - ._HTT_clone_information.xlsx
    
    278 Bytes
  - ._pBMDEL.FASTA
    
    384 Bytes
- 2 - Expression and purification of HTT and HTT-HAP40 Q23
  - ._Large scale expression and purification of full-length huntingtin Q19 and Q23 from baculoviral expression system production in sf9 insect cells ΓÇô 2018-07-06.pdf
    
    1.0 kB
  - ._Large scale expression and purification of full-length huntingtin Q23 with HAP40 in BVES sf9 insect cells ΓÇô 20180528.pdf
    
    617 Bytes
  - ._Purification of HTT and HTT-HAP40.docx
    
    490 Bytes
  - ._Purification of HTT and HTT-HAP40.pdf
    
    390 Bytes
  - ._Purification of HTT and HTT.docx
    
    490 Bytes
- 3 - Mass spectometry analysis of HTT samples
  - ._.DS_Store
    
    120 Bytes
  - ._NetPhos_HTT.rtfd
    
    176 Bytes
  - HTT_1-3144_Q23_EXPI293F
    - ._protein-peptides_allHEKQ23.xlsx
      
      334 Bytes
  - HTT_1-3144_Q23_Sf9
    - ._.DS_Store
      
      120 Bytes
    - ._protein-peptides_MtALP_WtALP_lowered_p value cutoff.csv
      
      233 Bytes
    - Htt - trypsin MtALP WtALP_lowered p value cutoff
      - ._protein-peptides_MtALP_WtALP_lowered_p value cutoff.csv
        
        233 Bytes
    - Htt lysarg trypsin 4hr_18hr_PTM 14_313 mods
      - ._PSM ions.csv
        
        233 Bytes
      - ._protein-peptides.csv
        
        244 Bytes
    - Q23 sf9_all enzymes
      - ._protein-peptides.csv
        
        233 Bytes
      - ._protein-peptides_allQ23.xlsx
        
        334 Bytes
      - ._protein-peptides_allQ23_sf9.xlsx
        
        278 Bytes
      - ._protein-peptides_all_Q23.csv
        
        278 Bytes
  - NetPhos_HTT.rtfd
    - ._TXT.rtf
      
      178 Bytes
  - PNG_Spectra_files
    - ._.DS_Store
      
      120 Bytes
    - ._Htt-HEK-solution-tryp.ai
      
      295 Bytes
    - ._Htt-HEK-solution-tryp_AALPS-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_AALPS-2.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_EKE.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_EPGEQ-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_HSLsSTK-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_PQF--K2996me-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_RHSL-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_RHSL-2.ai
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_RHSL-2.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_RHSLSStK-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-1.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-2.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-3.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-4.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-5.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-6.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-7.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-8.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SGS-9.png
      
      239 Bytes
    - ._Htt-HEK-solution-tryp_SSHLPSR-1.png
      
      239 Bytes
    - ._Htt-Q23-Sf9 - 2.ai
      
      239 Bytes
    - ._Htt-Q23-Sf9.ai
      
      295 Bytes
    - ._Htt-Sf9 all_TPPPELLQTLt.png
      
      239 Bytes
    - ._Htt-Sf9-all-RHSLSStK.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-pepsin_pH1_ASVPLS-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-pepsin_pH1_ASVPLS-2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-pepsin_pH1_DGDGHVSL-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-pepsin_pH1_IAGGGS-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-pepsin_pH1_PLLPQPQ-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-pepsin_pH1_PLLPQPQ-2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp4hr_S95_T97_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_ALALS719_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_ALALS719_2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_ALALSC_me-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_CRPYLVNLLPCLT216_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_CRmePYLVN-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_CWT2112RSDSA_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_DTSLKGS337_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_GQkS2164ALFEAAR_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_GYNLL_S997_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_IIQLcDGIMAS1532_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_IQS1959_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_KVS1398TQL_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_LLSPQMS1874_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_LLSPQMS1876_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_PeaksPTM14_T2112Rme2-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_PeaksPTM14_WT2112-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_PeaksPTM14_WT2112-2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1398_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1511_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1513KQIIGIPK_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1709_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S1959-2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S337_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S785_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S785_2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S819_2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S822_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_S997_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_SIIRme1-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T1403NLTSVT_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T1403_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T1406_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T269_S273-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_T900_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_TLTGNT801FS803_2.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_TLTGNT801_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_YHS1511kQIIGIPK_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017_cWtrSD-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017rerun4hrMar18_S1874_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017rerun4hrMar18_S411_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-soln-tryp_lysarg_Oct2017rerun4hrMar18_S621_1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_AALPS-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_AALPS-2.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_AALPS-3.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_ASAPKSLR-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_EKE-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_EPGEQA-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_HSLSSTK-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_IAGGG-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_RHSLSSTK-1.png
      
      238 Bytes
    - ._HttQ23-Sf9-solution-tryp_SGS-1.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_SGS-2.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_SGS-3.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_SGS-4.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_SGS-5.png
      
      239 Bytes
    - ._HttQ23-Sf9-solution-tryp_VGALHme-1.png
      
      239 Bytes
    - ._HttQ23-hek-gel band-tryp_H2786me-3.png
      
      239 Bytes
    - ._HttQ23-hek-gel band-tryp_S1106-1.png
      
      239 Bytes
    - ._HttQ23-hek-gel band-tryp_S2690_1.png
      
      239 Bytes
    - ._HttQ23-hek-soln-tryp_H2774me.png
      
      239 Bytes
    - ._HttQ23-hek-soln-tryp_H2786me-2.png
      
      239 Bytes
    - ._HttQ23-hek-soln-tryp_K2998me.png
      
      239 Bytes
    - ._HttQ23-hek-soln-tryp_R2779me1_1.png
      
      239 Bytes
    - ._HttQ23-hek-soln-tryp_R2781me-1.png
      
      239 Bytes
    - ._HttQ23-hek-soln-tryp_T1306ub_1.png
      
      239 Bytes
    - ._Q23 Sf9 Tryp solution 4hr rerun_T3055-1.png
      
      239 Bytes
    - ._Q23 Sf9 all data_H2796me-1.png
      
      239 Bytes
    - ._Q23 Sf9 pepsin_S2029-1.png
      
      239 Bytes
    - ._SGSphospho1.png
      
      239 Bytes
    - ._Sf9 lysarg_tryp_T271_S275.png
      
      239 Bytes
    - ._SmeITYGTGSMTGILGY.png
      
      239 Bytes
  - Sequence_coverage
    - ._.DS_Store
      
      120 Bytes
    - ._Q23 HEK293 band.png
      
      239 Bytes
    - ._Q23 HEK293.png
      
      239 Bytes
    - ._Sf9 all enzymes.png
      
      239 Bytes
    - ._Sf9 lysarg and trypsin.png
      
      352 Bytes
- 4 - SEC-MALS and DSLS analysis of HTT and HTT-HAP40
  - ._DSLS_HTT_Q19234254_20181005.pzfx
    
    252 Bytes
  - ._HTT_DSLS_20180503.xlsx
    
    334 Bytes
  - ._HTT_HAP40_DSLS.pzfx
    
    423 Bytes
  - ._HTT_HAP40_DSLS_20181013.xlsx
    
    334 Bytes
  - ._MALS_Raw_data_summary_20181130.xlsx
    
    278 Bytes
  - ._MALS_summary.pzfx
    
    333 Bytes
- 5 - SAXS data and molecular modelling
  - ._.DS_Store
    
    120 Bytes
  - SAXS
    - ._Buffer_Shunt13144buf1_00058.avg
      
      212 Bytes
    - ._Buffer_Shunt13144buf_00052.avg
      
      212 Bytes
    - ._Buffer_Shunthapbuf_00064.avg
      
      212 Bytes
    - ._HTT_05mgml_Shunt13144a05_00053.avg
      
      212 Bytes
    - ._HTT_05mgml_Shunt13144a05a_00061.avg
      
      212 Bytes
    - ._HTT_1mgml_Shunt13144a10_00054.avg
      
      212 Bytes
    - ._HTT_1mgml_Shunt13144a1a_00060.avg
      
      212 Bytes
    - ._HTT_2mgml_Shunt13144a20_00055.avg
      
      212 Bytes
    - ._HTT_2mgml_Shunt13144a2a_00059.avg
      
      212 Bytes
    - ._HTT_4mgml_Shunt13144a40_00057.avg
      
      212 Bytes
    - ._HTT_HAP40_05mgml_Shunthap05_00070.avg
      
      212 Bytes
    - ._HTT_HAP40_05mgml_Shunthap05a_00068.avg
      
      212 Bytes
    - ._HTT_HAP40_1mgml_Shunthap1_00066.avg
      
      212 Bytes
    - ._HTT_HAP40_1mgml_Shunthap1a_00067.avg
      
      212 Bytes
    - ._HTT_HAP40_2mgml_Shunthap2all_00065.avg
      
      212 Bytes
    - ._HTT_HAP40_2mgml_Shunthap2sel_00065.avg
      
      212 Bytes
    - ._hulison062018.pxp
      
      268 Bytes
  - SES_ensemble
    - ._hthpses2_5.list
      
      174 Bytes
    - ._test10_trj_17w.pdb
      
      174 Bytes
    - ._test10_trj_95w.pdb
      
      174 Bytes
    - ._test1_trj_159w.pdb
      
      174 Bytes
    - ._test1_trj_184w.pdb
      
      174 Bytes
    - ._test3_trj_200w.pdb
      
      174 Bytes
  - WAXS
    - ._Buffer_Whunt13144buf1_00058.avg
      
      212 Bytes
    - ._Buffer_Whunt13144buf_00052.avg
      
      212 Bytes
    - ._Buffer_Whunthapbuf_00064.avg
      
      212 Bytes
    - ._HTT_05mgml_Whunt13144a05_00053.avg
      
      212 Bytes
    - ._HTT_05mgml_Whunt13144a05a_00061.avg
      
      212 Bytes
    - ._HTT_1mgml_Whunt13144a10_00054.avg
      
      212 Bytes
    - ._HTT_1mgml_Whunt13144a1a_00060.avg
      
      212 Bytes
    - ._HTT_2mgml_Whunt13144a20_00055.avg
      
      212 Bytes
    - ._HTT_2mgml_Whunt13144a2a_00059.avg
      
      212 Bytes
    - ._HTT_4mgml_Whunt13144a40_00057.avg
      
      212 Bytes
    - ._HTT_HAP40_05mgml_Whunthap05_00070.avg
      
      212 Bytes
    - ._HTT_HAP40_05mgml_Whunthap05a_00068.avg
      
      212 Bytes
    - ._HTT_HAP40_1mgml_Whunthap1_00066.avg
      
      212 Bytes
    - ._HTT_HAP40_1mgml_Whunthap1a_00067.avg
      
      212 Bytes
    - ._HTT_HAP40_2mgml_Whunthap2_00065.avg
      
      212 Bytes
- 6 - Manuscript
  - ._Harding_Huntingtin_manuscript_20181210.docx
    
    490 Bytes
  - ._Harding_Huntingtin_manuscript_20181210.pdf
    
    210 Bytes

HTT_Manuscript_20181210.zip