Conference paper Open Access

In Silico analysis of stent deployment - effect of stent design

Georgia S. Karanasiou; Nikolaos S. Tachos; Antonios Sakellarios; Claire Conway; Giancarlo Pennati; Lorenza Petrini; Lampros K. Michalis; Elazer R. Edelman; Dimitrios I. Fotiadis


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    <subfield code="a">stent, design, strut thickness, modeling, FEA, in silico</subfield>
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    <subfield code="a">Nikolaos S. Tachos</subfield>
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    <subfield code="a">Antonios Sakellarios</subfield>
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    <subfield code="u">Institute for Medical Engineering and Science, Massachusetts Institute of Technology</subfield>
    <subfield code="a">Claire Conway</subfield>
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    <subfield code="u">Department of Civil and Environmental Engineering, Politecnico di Milano,</subfield>
    <subfield code="a">Giancarlo Pennati</subfield>
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    <subfield code="u">Department of Civil and Environmental Engineering, Politecnico di Milano,</subfield>
    <subfield code="a">Lorenza Petrini</subfield>
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    <subfield code="u">Department of Cardiology, Medical School, University of Ioannina,</subfield>
    <subfield code="a">Lampros K. Michalis</subfield>
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    <subfield code="u">Institute for Medical Engineering and Science, Massachusetts Institute of Technology</subfield>
    <subfield code="a">Elazer R. Edelman</subfield>
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    <subfield code="u">Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, FORTH, Ioannina, Greece and the Dept. of Materials Science and Engineering, Unit of Medical Technology and Intelligent Information Systems, University of Ioannina</subfield>
    <subfield code="a">Dimitrios I. Fotiadis</subfield>
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    <subfield code="c">2018-07-22</subfield>
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    <subfield code="u">FORTH</subfield>
    <subfield code="a">Georgia S. Karanasiou</subfield>
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    <subfield code="a">In Silico analysis of stent deployment - effect of stent design</subfield>
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    <subfield code="c">777119</subfield>
    <subfield code="a">InSilc: In-silico trials for drug-eluting BVS design, development and evaluation</subfield>
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    <subfield code="a">&lt;p&gt;Coronary artery disease (CAD) remains the leading cause of death in Europe and worldwide. One of the most common pathologic processes involved in CAD is atherosclerosis. Coronary stents are expandable scaffolds that are used to widen the occluded arteries and enable the blood flow restoration. To achieve an adequate delivery and placement of coronary stents different parameters play a significant role. Due to the strain that the stents are exposed to and the forces they should withstand, the stent design is dominant. This study focuses on investigating the effect of the stent design in two finite element models using two stents with difference in the strut thickness. The in silico deployment is performed in a reconstructed patient specific arterial segment. The results are analyzed in terms of stress in the stent and the arterial wall and demonstrate how stent expansion is extensively affected by the scaffold&amp;rsquo;s design&lt;/p&gt;</subfield>
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