Journal article Open Access

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

Sameer Joshi; Maryam T. Hussain; Carla B. Roces; Giulia Anderluzzi; Elisabeth Kastner; Stefano Salmaso; Daniel J. Kirby; Yvonne Perrie


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="942" ind1=" " ind2=" ">
    <subfield code="a">2017-05-30</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">liposomes</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">microfluidics</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">water soluble drugs</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">poorly soluble drugs</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">bilayer loading</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">aqueous soluble drug</subfield>
  </datafield>
  <controlfield tag="005">20200120170711.0</controlfield>
  <controlfield tag="001">197095</controlfield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 7 Cathedral Street, Glasgow, UK. G4 0RE</subfield>
    <subfield code="a">Maryam T. Hussain</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 7 Cathedral Street, Glasgow, UK. G4 0RE</subfield>
    <subfield code="a">Carla B. Roces</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via 9 Marzolo 5, 35131 Padova - Italy</subfield>
    <subfield code="a">Giulia Anderluzzi</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Aston Pharmacy School, Life and Health Sciences, Aston University, Birmingham, UK. B4 7ET</subfield>
    <subfield code="a">Elisabeth Kastner</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via 9 Marzolo 5, 35131 Padova - Italy</subfield>
    <subfield code="a">Stefano Salmaso</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Aston Pharmacy School, Life and Health Sciences, Aston University, Birmingham, UK. B4 7ET</subfield>
    <subfield code="a">Daniel J. Kirby</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 7 Cathedral Street, Glasgow, UK. G4 0RE</subfield>
    <subfield code="a">Yvonne Perrie</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">548595</subfield>
    <subfield code="z">md5:d646f14f3764de3b1c1ebbf0c94512d0</subfield>
    <subfield code="u">https://zenodo.org/record/197095/files/Joshi_etal_IJP2016_Microfluidics_based_manufacture_of_liposomes.pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2016-11-15</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="p">user-ecfunded</subfield>
    <subfield code="o">oai:zenodo.org:197095</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="c">160–168</subfield>
    <subfield code="n">1</subfield>
    <subfield code="p">International Journal of Pharmaceutics</subfield>
    <subfield code="v">514</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Aston Pharmacy School, Life and Health Sciences, Aston University, Birmingham, UK. B4 7ET</subfield>
    <subfield code="a">Sameer Joshi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-ecfunded</subfield>
  </datafield>
  <datafield tag="536" ind1=" " ind2=" ">
    <subfield code="c">643381</subfield>
    <subfield code="a">TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution Non Commercial No Derivatives 4.0 International</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2=" ">
    <subfield code="a">Drug delivery systems</subfield>
    <subfield code="0">(url)http://id.loc.gov/authorities/subjects/sh88007108</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Despite the substantial body of research investigating the use of liposomes, niosomes and other bilayer vesicles for drug delivery, the translation of these systems into licensed products remains limited. Indeed, recent shortages in the supply of liposomal products demonstrate the need for new scalable production methods for liposomes. Therefore, the aim of our research has been to consider the application of microfluidics in the manufacture of liposomes containing either or both a water soluble and a lipid soluble drug to promote co-delivery of drugs.  For the first time, we demonstrate the entrapment of a hydrophilic and a lipophilic drug (metformin and glipizide respectively) both individually and in combination using a scalable microfluidics manufacturing system. In terms of the operating parameters, the choice of solvents, lipid concentration and aqueous:solvent ratio all impact on liposome size with vesicle diameter ranging from ~90 to 300 nm. In terms of drug loading, microfluidics production promoted high loading within  ~100 nm vesicles for both the water soluble drug (20 - 25% of initial amount added) and the bilayer embedded drug (40 – 42% of initial amount added) with co-loading of the drugs making no impact on entrapment efficacy. However, co-loading of glipizide and metformin within the same liposome formulation did impact on the drug release profiles; in both instances the presence of both drugs in the one formulation promoted faster (up to 2 fold) release compared to liposomes containing a single drug alone.  Overall, these results demonstrate the application of microfluidics to prepare liposomal systems incorporating either or both an aqueous soluble drug and a bilayer loaded drug.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">url</subfield>
    <subfield code="i">isIdenticalTo</subfield>
    <subfield code="a">http://strathprints.strath.ac.uk/57040/</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">doi</subfield>
    <subfield code="i">isPreviousVersionOf</subfield>
    <subfield code="a">10.1016/j.ijpharm.2016.09.027</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.5281/zenodo.197095</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
</record>
57
26
views
downloads
All versions This version
Views 5757
Downloads 2626
Data volume 14.3 MB14.3 MB
Unique views 5656
Unique downloads 2424

Share

Cite as