{ "access": { "embargo": { "active": false, "reason": null }, "files": "public", "record": "public", "status": "open" }, "created": "2016-11-30T16:15:51.989935+00:00", "custom_fields": { "journal:journal": { "issue": "1", "pages": "38", "title": "Alzheimer's Research & Therapy", "volume": "8" } }, "deletion_status": { "is_deleted": false, "status": "P" }, "files": { "count": 1, "enabled": true, "entries": { "Saint-Aubert_AlzResTher_2016-P12b.pdf": { "checksum": "md5:c48133d31c070d602ed2b38a423745b5", "ext": "pdf", "id": "7672dd7d-8ce1-4c35-9043-da148be78c71", "key": "Saint-Aubert_AlzResTher_2016-P12b.pdf", "metadata": null, "mimetype": "application/pdf", "size": 1184238 } }, "order": [], "total_bytes": 1184238 }, "id": "189059", "is_draft": false, "is_published": true, "links": { "access": "https://zenodo.org/api/records/189059/access", "access_links": "https://zenodo.org/api/records/189059/access/links", "access_request": "https://zenodo.org/api/records/189059/access/request", "access_users": "https://zenodo.org/api/records/189059/access/users", "archive": "https://zenodo.org/api/records/189059/files-archive", "archive_media": "https://zenodo.org/api/records/189059/media-files-archive", "communities": "https://zenodo.org/api/records/189059/communities", "communities-suggestions": "https://zenodo.org/api/records/189059/communities-suggestions", "doi": "https://doi.org/10.1186/s13195-016-0204-z", "draft": "https://zenodo.org/api/records/189059/draft", "files": "https://zenodo.org/api/records/189059/files", "latest": "https://zenodo.org/api/records/189059/versions/latest", "latest_html": "https://zenodo.org/records/189059/latest", "media_files": "https://zenodo.org/api/records/189059/media-files", "parent": "https://zenodo.org/api/records/667049", "parent_doi": "https://zenodo.org/doi/", "parent_html": "https://zenodo.org/records/667049", "requests": "https://zenodo.org/api/records/189059/requests", "reserve_doi": "https://zenodo.org/api/records/189059/draft/pids/doi", "self": "https://zenodo.org/api/records/189059", "self_doi": "https://zenodo.org/doi/10.1186/s13195-016-0204-z", "self_html": "https://zenodo.org/records/189059", "self_iiif_manifest": "https://zenodo.org/api/iiif/record:189059/manifest", "self_iiif_sequence": "https://zenodo.org/api/iiif/record:189059/sequence/default", "versions": "https://zenodo.org/api/records/189059/versions" }, "media_files": { "count": 0, "enabled": false, "entries": {}, "order": [], "total_bytes": 0 }, "metadata": { "creators": [ { "affiliations": [ { "name": "Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge 141 57, Sweden." } ], "person_or_org": { "family_name": "Saint-Aubert", "given_name": "Laure", "name": "Saint-Aubert, Laure", "type": "personal" } }, { "affiliations": [ { "name": "Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge 141 57, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden and Department of Psychology, Stockholm University, Stockholm, Sweden." } ], "person_or_org": { "family_name": "Almkvist", "given_name": "Ove", "name": "Almkvist, Ove", "type": "personal" } }, { "affiliations": [ { "name": "Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge 141 57, Sweden." } ], "person_or_org": { "family_name": "Chiotis", "given_name": "Konstantinos", "name": "Chiotis, Konstantinos", "type": "personal" } }, { "affiliations": [ { "name": "Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden." } ], "person_or_org": { "family_name": "Almeida", "given_name": "Rita", "name": "Almeida, Rita", "type": "personal" } }, { "affiliations": [ { "name": "PET Centre, Uppsala University Hospital, Uppsala, Sweden and Nuclear medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden." } ], "person_or_org": { "family_name": "Wall", "given_name": "Anders", "name": "Wall, Anders", "type": "personal" } }, { "affiliations": [ { "name": "Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Novum 5th floor, Huddinge 141 57, Sweden and Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden." } ], "person_or_org": { "family_name": "Nordberg", "given_name": "Agneta", "name": "Nordberg, Agneta", "type": "personal" } } ], "description": "
BACKGROUND: The recent development of tau-specific positron emission tomography (PET) tracers has allowed in vivo quantification of regional tau deposition and offers the opportunity to monitor the progression of tau pathology along with cognitive impairment. In this study, we investigated the relationships of cerebral tau deposition ([18F]THK5317-PET) and metabolism ([18F]FDG-PET) with concomitant cognitive function in patients with probable Alzheimer's disease (AD).
\n\nMETHODS: Nine patients diagnosed with AD dementia and 11 with prodromal AD (mild cognitive impairment, amyloid-positive on [11C]PiB-PET) were included in this study. All patients underwent PET scans using each tracer, as well as episodic memory and global cognition assessment. Linear models were used to investigate the association of regional [18F]THK5317 retention and [18F]FDG uptake with cognition. The possible mediating effect of local metabolism on the relationship between tau deposition and cognitive performance was investigated using mediation analyses.
\n\nRESULTS: Significant negative associations were found between [18F]THK5317 regional retention, mainly in temporal regions, and both episodic memory and global cognition. Significant positive associations were found between [18F]FDG regional uptake and cognition. The association of [18F]FDG with global cognition was regionally more extensive than that of [18F]THK5317, while the opposite was observed with episodic memory, suggesting that [18F]THK5317 retention might be more sensitive than [18F]FDG regional uptake to early cognitive impairment. Finally, [18F]FDG uptake had a mediating effect on the relationship between [18F]THK5317 retention in temporal regions and global cognition.
\n\nCONCLUSIONS: These findings suggest a mediating role for local glucose metabolism in the observed association between in vivo tau deposition and concomitant cognitive impairment in AD.
", "funding": [ { "award": { "acronym": "INMIND", "id": "00k4n6c32::278850", "identifiers": [ { "identifier": "https://cordis.europa.eu/projects/278850", "scheme": "url" } ], "number": "278850", "program": "FP7", "title": { "en": "Imaging of Neuroinflammation in Neurodegenerative Diseases" } }, "funder": { "id": "00k4n6c32", "name": "European Commission" } } ], "publication_date": "2016-09-29", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Cognition" }, { "subject": "Memory" }, { "subject": "Metabolism" }, { "subject": "Positron emission tomography (PET)" }, { "subject": "Tau imaging" } ], "title": "Regional tau deposition measured by [18F]THK5317 positron emission tomography is associated to cognition via glucose metabolism in Alzheimer's disease." }, "parent": { "access": { "owned_by": { "user": 1964 } }, "communities": { "default": "724cc757-0e37-4b01-a81f-b8aa5f1d7b44", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2014-01-06T13:42:25+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "724cc757-0e37-4b01-a81f-b8aa5f1d7b44", "links": {}, "metadata": { "curation_policy": "all uploads acknowledging the INMiND project are accepted", "page": "The goal of the EC FP7 Collaborative Project INMiND (GA 278850) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into clinical application and patient benefit.
\r\n\r\n\r\n\r\n
The general objectives of INMiND are:
\r\n\r\n(i) to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems);
\r\n\r\n(ii) to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes;
\r\n\r\n(iii) to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo innovative model systems and in patients;
\r\n\r\n(iv) to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment, and to relate the findings to clinical outcome.
\r\n\r\nThe INMiND projects brings together a group of excellent basic scientists and clinicians with a proven background in efficiently accomplishing common scientific goals (FP6 DiMI, www.dimi.eu), who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation-related neurodegenerative diseases.
\r\n\r\nThe strength of the project is that, across Europe, it coordinates research and training activities related to neuroinflammation, neurodegeneration, neuroregeneration, and imaging with special emphasis on translating basic mechanisms into clinical applications that shall provide health benefits for our aging population.
\r\n\r\nWith its intellectual excellence and its crucial mass the INMiND consortium is playing a major role in the European Research Area and will gain European leadership in the creation of new image-guided diagnosis and therapy paradigms in patients with neurodegenerative diseases.
", "title": "INMiND - Imaging of Neuroinflammation in Neurodegenerative Diseases" }, "revision_id": 0, "slug": "inmind", "updated": "2016-09-28T07:01:51.111318+00:00" }, { "access": { "member_policy": "open", "members_visibility": "restricted", "record_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
\nZenodo’s general policies and Terms of Use apply to all content.
\nThe EU Open Research Repository accepts all digital research objects which is a research output stemming from one of EU’s research and innovation funding programmes. The funding programmes currently include:
\nHorizon Europe (including ERC, MSCA), earlier Framework Programmes (eg Horizon 2020) as well as Euratom.
\nIn line with the principle as open as possible, as closed as necessary both public and restricted content is accepted. See note on how Zenodo handles restricted content.
\nEU programme beneficiaries are eligible to submit content to the community. The community supports three types of content submissions:
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\nA representative of an EU project may request an EU Project Community and invite other project participants as members of the community. The project community is linked to one or more European Commission grants. All records in the project community are automatically integrated into the EU Open Research Repository immediately upon acceptance into the project community.
\nAny user may submit a record directly to the EU Open Research Repository. The submission will be moderated by Zenodo staff for compliance with the minimal required metadata requirements and its correctness.
\nRecords found among Zenodo’s existing content will on a regular basis automatically be integrated if they are found to comply with the requirements. The submissions through this method are integrated into the EU Open Research Repository with delay in a fully automated way.
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\nSubjects: Records SHOULD specify one or more fields of science from the European Science Vocabulary.
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\nCommunity curators may at any point edit metadata of the records in the community without notice through human or automated processing. The curators may at their sole discretion remove records from the community that are deemed not to comply with the content and curation policy or which are deemed of insufficient quality.
\nThe content and curation policy is subject to change by the community owner at any time and without notice, other than through updating this page.
", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom and earlier Framework Programmes.", "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
\nThe EU Open Research Repository serves as a complementary platform to the Open Research Europe (ORE) publishing platform. Open Research Europe focuses on providing a publishing venue for peer-reviewed articles, ensuring that research meets rigorous academic standards. The EU Open Research Repository provides a space for all the other research outputs including data sets, software, posters, and presentations that are out of scope for ORE. This holistic approach enables researchers to not only publish their findings but also share the underlying data and materials that support their work, fostering transparency and reproducibility in the scientific process.
\nCurrently in its pilot phase and set to be fully operational during autumn 2024, the EU Open Research Repository is constantly evolving. Efforts are committed to integrating cutting-edge features, including automated curation checks and FAIR (Findable, Accessible, Interoperable, and Reusable) assistance, to further support the research community. The goal is to provide researchers with a simple goto solution for making their publicly funded research open and as FAIR as possible.
\nThe EU Open Research Repository is funded by the European Union under grant agreement no. 101122956(HORIZON-ZEN). For more information about the project see https://about.zenodo.org/projects/horizon-zen/.
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