PsPM-DoxMem1 dataset
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Repository Version: 2018.12.03

This dataset includes skin conductance response (SCR), electrocardiogram (ECG), respiration and electromyogramm (EMG, only relevant for retention phase) measurements. Also included are CS and US information, keypress responses and keypress response times for 78 healthy participants (40 males and 38 females aged 23.3+/-3.6 years) under either doxycycline or placebo during a classical (Pavlovian) discriminant delay fear conditioning task. CS were a red and a blue screen. US consisted of 0.5 s square electric pulses with participant-specific duration and 500 Hz frequency. SOA between the CS onset and US was 3.5 s. CS and US co-terminated. Before the fear conditioning task, participants completed an N-back task and several questionnaires. During the retention/extinction phase one week after learning and without drug, an auditory startle probe (ST) and no US was delivered 3.5 s after CS onset via headphones (100 dB, 50 ms duration with 2ms on- and offset ramp). In an immediately following re-learning phase, the ST was omitted and the CS reinforced with the same schedule as during acquisition. The ITI was randomly determined on each trial to be 7, 9, or 11 s.

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This repository is curated by the PsPM team, pspm.sourceforge.net

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Dataset is described and used in following references:
- Dominik R. Bach & Athina Tzovara & Johanna Vunder (2018) Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline. Molecular Psychiatry, 23:7, pp 1584--1589. DOI:10.1038/mp.2017.65

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File Structure:
-README.txt               // This document
-+Data                    // Folder Containing all data files
|-DoxMem1_wdq_XX_snY.mat       // 156 files holding measurements for SCR, ECG, respiration, EMG
|-DoxMem1_cogent_XX_snY.mat    // 156 files holding key presses, CS/US/ST information, demographics and questionnaire scores, and drug information
|-DoxMem1_NBack_Y.mat // 78 files holding NBack task results
|-DoxMem1_SetUS_Y.mat // 78 files holding ratings of the pain stimulus delivered as US

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Data Files:
- Files holding SCR, EMG, ECG, respiration traces and time markers, recorded with WDQ software.
  - Skin conductance (channel 1)
  - Electromyogram (channel 2)
  - Electrocardiogram (channel 3)
  - Respiration (channel 4)
  - Startle sounds (channel 5)
  - Event markers used for synchronization with Cogent files, markers are set at CS presentation onset (channel 6)
- Files holding keyboard presses and CS/US information, recorded with Cogent 2000 software. Also contains demographic (age, sex), physical (weight/height) and psychometric (BDI, STAI, BISBAS) information, US characteristics (amplitude, pulse width) and drug status (0: placebo; 1: 200 mg doxycycline).
- Files holding data from the NBack-task, recorded with Cogent 2000 software.
- Files holding data from intensity ratings on random electric stimulations, at 4 different time points during the study.

The data file name is composed of:
- DoxMem1     The dataset name
- wdq/cogent/Nback/SetUS   The type of data recorded (see above)
- XX           The subject number
- Y            The session number

Data are stored as .mat files for use with MATLAB (The MathWorks Inc., Natick, USA) in a format readable by the PsPM toolbox (pspm.sourceforge.net). All Matlab files are saved in MATLAB 9.2 (R2017a) format.