Journal article Open Access

Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery

Connor, Duffy; David, Laurent; Crouzier, Thomas


Citation Style Language JSON Export

{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.17922", 
  "container_title": "Acta Biomaterialia", 
  "title": "Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery", 
  "issued": {
    "date-parts": [
      [
        2015, 
        5, 
        1
      ]
    ]
  }, 
  "abstract": "<p>The sustained delivery of both hydrophobic and hydrophilic drugs from hydrogels has remained a challenge requiring the design and scalable production of complex multifunctional synthetic polymers. Here, we demonstrate that mucin glycoproteins, the gel-forming constituents of native mucus, are suitable for assembly into robust hydrogels capable of facilitating the sustained release of hydrophobic and hydrophilic drugs. Covalently-crosslinked mucin hydrogels were generated via exposure of methacrylated mucin to ultraviolet light in the presence of a free radical photoinitiator. The hydrogels exhibited an elastic modulus similar to that of soft mammalian tissue and were sensitive to proteolytic degradation by pronase. Paclitaxel, a hydrophobic anti-cancer drug, and polymyxin B, a positively-charged hydrophilic antibacterial drug, were retained in the hydrogels and released linearly with time over seven days. After four weeks of drug release, the hydrogels continued to release sufficient amounts of active paclitaxel to reduce HeLa cell viability and sufficient amounts of active polymyxin B to prevent bacterial proliferation. Along with previously-established anti-inflammatory, anti-viral, and hydrocarbon-solubilizing properties of mucin, the results of this study establish mucin as a readily-available, chemically-versatile, naturally-biocompatible alternative to complex multifunctional synthetic polymers as building blocks in the design of biomaterials for sustained drug delivery.</p>", 
  "author": [
    {
      "given": "Duffy", 
      "family": "Connor"
    }, 
    {
      "given": "Laurent", 
      "family": "David"
    }, 
    {
      "given": "Thomas", 
      "family": "Crouzier"
    }
  ], 
  "page": "51\u201359", 
  "volume": "20", 
  "type": "article-journal", 
  "id": "17922"
}
125
15
views
downloads
All versions This version
Views 125125
Downloads 1515
Data volume 39.5 MB39.5 MB
Unique views 125125
Unique downloads 1414

Share

Cite as