Journal article Open Access

Lactation-induced reduction in hippocampal neurogenesis is reversed by chronic stress exposure

Hillerer, Katharina M; Neumann, Inga D; Couillard-Despres, Sebastien; Aigner, Ludwig; Slattery, David A


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  <identifier identifierType="URL">https://zenodo.org/record/16899</identifier>
  <creators>
    <creator>
      <creatorName>Hillerer, Katharina M</creatorName>
      <givenName>Katharina M</givenName>
      <familyName>Hillerer</familyName>
      <affiliation>epartment of Behavioural and Molecular Neurobiology, University of Regensburg, Germany and Department of Obstetrics and Gynaecology, Salzburger Landeskrankenhaus (SALK), Paracelsus Medical University, Austria</affiliation>
    </creator>
    <creator>
      <creatorName>Neumann, Inga D</creatorName>
      <givenName>Inga D</givenName>
      <familyName>Neumann</familyName>
      <affiliation>epartment of Behavioural and Molecular Neurobiology, University of Regensburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Couillard-Despres, Sebastien</creatorName>
      <givenName>Sebastien</givenName>
      <familyName>Couillard-Despres</familyName>
      <affiliation>Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria</affiliation>
    </creator>
    <creator>
      <creatorName>Aigner, Ludwig</creatorName>
      <givenName>Ludwig</givenName>
      <familyName>Aigner</familyName>
      <affiliation>Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria</affiliation>
    </creator>
    <creator>
      <creatorName>Slattery, David A</creatorName>
      <givenName>David A</givenName>
      <familyName>Slattery</familyName>
      <affiliation>epartment of Behavioural and Molecular Neurobiology, University of Regensburg, Germany</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Lactation-induced reduction in hippocampal neurogenesis is reversed by chronic stress exposure</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2014</publicationYear>
  <subjects>
    <subject>lactation</subject>
    <subject>hippocampal volume</subject>
    <subject>neurons</subject>
    <subject>differentiation</subject>
    <subject> corticosterone</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2014-02-12</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/16899</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/hipo.22258</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The peripartum period is a time of high susceptibility for mood and anxiety disorders, some of which have recently been associated with alterations in hippocampal neurogenesis. Several factors including stress, aging, and, perhaps unexpectedly, lactation have been shown to decrease hippocampal neurogenesis. Intriguingly, lactation is also a time of reduced stress responsivity suggesting that the effect of stress on neurogenic processes may differ during this period. Therefore, the aim of the present study was to assess the effect of repeated stress during lactation [2 h restraint stress from lactation day (LD) 2 to LD13] on brain weight, hippocampal volume, cell proliferation and survival, and on neuronal and astroglial differentiation. In addition to confirming the known lactation-associated decrease in cell proliferation and survival, we could reveal that stress reversed the lactation-induced decrease in cell proliferation, while it did not affect survival of newly born cells, nor the number of mature neurons , nor did it alter immature neuron production or the number of astroglial cells in lactation. Stress exposure increased relative brain weight and hippocampal volume mirroring the observed changes in neurogenesis. Interestingly, hippocampal volume and relative brain weight were lower in lactation as compared to nulliparous females under nonstressed conditions. This study assessed the effect of stress during lactation on hippocampal neurogenesis and indicates that stress interferes with important peripartum adaptations at the level of the hippocampus.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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