Journal article Open Access

(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Rotstein, Benjamin H; Liang, Steven H; Placzek, Michael S; Hooker, Jakob M; Gee, Antony D; Dollé, Frédéric; Wilson, Alan A; Vasdev, Neil

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<oai_dc:dc xmlns:dc="" xmlns:oai_dc="" xmlns:xsi="" xsi:schemaLocation="">
  <dc:creator>Rotstein, Benjamin H</dc:creator>
  <dc:creator>Liang, Steven H</dc:creator>
  <dc:creator>Placzek, Michael S</dc:creator>
  <dc:creator>Hooker, Jakob M</dc:creator>
  <dc:creator>Gee, Antony D</dc:creator>
  <dc:creator>Dollé, Frédéric</dc:creator>
  <dc:creator>Wilson, Alan A</dc:creator>
  <dc:creator>Vasdev, Neil</dc:creator>
  <dc:description>The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for in vivo positron emission tomography (PET) imaging. Carbon-11 is most often incorporated into small molecules by methylation of alcohol, thiol, amine or carboxylic acid precursors using [(11)C]methyl iodide or [(11)C]methyl triflate (generated from [(11)C]carbon dioxide or [(11)C]methane). Consequently, small molecules that lack an easily substituted (11)C-methyl group are often considered to have non-obvious strategies for radiolabeling and require a more customized approach. [(11)C]Carbon dioxide itself, [(11)C]carbon monoxide, [(11)C]cyanide, and [(11)C]phosgene represent alternative reactants to enable (11)C-carbonylation. Methodologies developed for preparation of (11)C-carbonyl groups have had a tremendous impact on the development of novel PET tracers and provided key tools for clinical research. (11)C-Carbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates and ureas now account for a substantial number of important imaging agents that have seen translation to higher species and clinical research of previously inaccessible targets, which is a testament to the creativity, utility and practicality of the underlying radiochemistry.</dc:description>
  <dc:source>Chem Soc Rev. 45(17) 4708-26</dc:source>
  <dc:subject>positron emission tomography</dc:subject>
  <dc:subject>carbon dioxide</dc:subject>
  <dc:subject>carbon monoxide</dc:subject>
  <dc:subject>hydrogen cyanide</dc:subject>
  <dc:subject>molecular imaging</dc:subject>
  <dc:title>(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.</dc:title>