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(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Rotstein, Benjamin H; Liang, Steven H; Placzek, Michael S; Hooker, Jakob M; Gee, Antony D; Dollé, Frédéric; Wilson, Alan A; Vasdev, Neil


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{
  "description": "<p>The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for in vivo positron emission tomography (PET) imaging. Carbon-11 is most often incorporated into small molecules by methylation of alcohol, thiol, amine or carboxylic acid precursors using [(11)C]methyl iodide or [(11)C]methyl triflate (generated from [(11)C]carbon dioxide or [(11)C]methane). Consequently, small molecules that lack an easily substituted (11)C-methyl group are often considered to have non-obvious strategies for radiolabeling and require a more customized approach. [(11)C]Carbon dioxide itself, [(11)C]carbon monoxide, [(11)C]cyanide, and [(11)C]phosgene represent alternative reactants to enable (11)C-carbonylation. Methodologies developed for preparation of (11)C-carbonyl groups have had a tremendous impact on the development of novel PET tracers and provided key tools for clinical research. (11)C-Carbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates and ureas now account for a substantial number of important imaging agents that have seen translation to higher species and clinical research of previously inaccessible targets, which is a testament to the creativity, utility and practicality of the underlying radiochemistry.</p>", 
  "license": "http://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Massachusetts General Hospital, Harvard Medical School, Boston, USA.", 
      "@type": "Person", 
      "name": "Rotstein, Benjamin H"
    }, 
    {
      "affiliation": "Massachusetts General Hospital, Harvard Medical School, Boston, USA.", 
      "@type": "Person", 
      "name": "Liang, Steven H"
    }, 
    {
      "affiliation": "Athinoula A. Martinos Center for Biomedical Imaging, MGH, HMS, Charlestown, USA and McLean Hospital, Belmont, USA", 
      "@type": "Person", 
      "name": "Placzek, Michael S"
    }, 
    {
      "affiliation": "Athinoula A. Martinos Center for Biomedical Imaging, MGH, HMS, Charlestown, USA", 
      "@type": "Person", 
      "name": "Hooker, Jakob M"
    }, 
    {
      "affiliation": "King\u2019s College London, London, UK", 
      "@type": "Person", 
      "name": "Gee, Antony D"
    }, 
    {
      "affiliation": "CEA \u2013 Institut d\u2019imagerie biom\u00e9dicale, Service hospitalier Fr\u00e9d\u00e9ric Joliot, Universit\u00e9 Paris-Saclay, Orsay, France", 
      "@type": "Person", 
      "name": "Doll\u00e9, Fr\u00e9d\u00e9ric"
    }, 
    {
      "affiliation": "Centre for Addiction and Mental Health, Toronto, Canada", 
      "@type": "Person", 
      "name": "Wilson, Alan A"
    }, 
    {
      "affiliation": "Massachusetts General Hospital, Harvard Medical School, Boston, USA.", 
      "@type": "Person", 
      "name": "Vasdev, Neil"
    }
  ], 
  "url": "https://zenodo.org/record/167921", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2016-06-08", 
  "headline": "(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.", 
  "keywords": [
    "carbon-11", 
    "positron emission tomography", 
    "radiochemistry,", 
    "carbon dioxide", 
    "phosgene", 
    "carbon monoxide", 
    "hydrogen cyanide", 
    "molecular imaging"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1039/c6cs00310a", 
  "@id": "https://doi.org/10.1039/c6cs00310a", 
  "@type": "ScholarlyArticle", 
  "name": "(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals."
}
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