Journal article Open Access

(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Rotstein, Benjamin H; Liang, Steven H; Placzek, Michael S; Hooker, Jakob M; Gee, Antony D; Dollé, Frédéric; Wilson, Alan A; Vasdev, Neil


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  <identifier identifierType="URL">https://zenodo.org/record/167921</identifier>
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    <creator>
      <creatorName>Rotstein, Benjamin H</creatorName>
      <givenName>Benjamin H</givenName>
      <familyName>Rotstein</familyName>
      <affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, USA.</affiliation>
    </creator>
    <creator>
      <creatorName>Liang, Steven H</creatorName>
      <givenName>Steven H</givenName>
      <familyName>Liang</familyName>
      <affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, USA.</affiliation>
    </creator>
    <creator>
      <creatorName>Placzek, Michael S</creatorName>
      <givenName>Michael S</givenName>
      <familyName>Placzek</familyName>
      <affiliation>Athinoula A. Martinos Center for Biomedical Imaging, MGH, HMS, Charlestown, USA and McLean Hospital, Belmont, USA</affiliation>
    </creator>
    <creator>
      <creatorName>Hooker, Jakob M</creatorName>
      <givenName>Jakob M</givenName>
      <familyName>Hooker</familyName>
      <affiliation>Athinoula A. Martinos Center for Biomedical Imaging, MGH, HMS, Charlestown, USA</affiliation>
    </creator>
    <creator>
      <creatorName>Gee, Antony D</creatorName>
      <givenName>Antony D</givenName>
      <familyName>Gee</familyName>
      <affiliation>King’s College London, London, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Dollé, Frédéric</creatorName>
      <givenName>Frédéric</givenName>
      <familyName>Dollé</familyName>
      <affiliation>CEA – Institut d’imagerie biomédicale, Service hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France</affiliation>
    </creator>
    <creator>
      <creatorName>Wilson, Alan A</creatorName>
      <givenName>Alan A</givenName>
      <familyName>Wilson</familyName>
      <affiliation>Centre for Addiction and Mental Health, Toronto, Canada</affiliation>
    </creator>
    <creator>
      <creatorName>Vasdev, Neil</creatorName>
      <givenName>Neil</givenName>
      <familyName>Vasdev</familyName>
      <affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, USA.</affiliation>
    </creator>
  </creators>
  <titles>
    <title>(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2016</publicationYear>
  <subjects>
    <subject>carbon-11</subject>
    <subject>positron emission tomography</subject>
    <subject>radiochemistry,</subject>
    <subject>carbon dioxide</subject>
    <subject>phosgene</subject>
    <subject>carbon monoxide</subject>
    <subject>hydrogen cyanide</subject>
    <subject>molecular imaging</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2016-06-08</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/167921</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c6cs00310a</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for in vivo positron emission tomography (PET) imaging. Carbon-11 is most often incorporated into small molecules by methylation of alcohol, thiol, amine or carboxylic acid precursors using [(11)C]methyl iodide or [(11)C]methyl triflate (generated from [(11)C]carbon dioxide or [(11)C]methane). Consequently, small molecules that lack an easily substituted (11)C-methyl group are often considered to have non-obvious strategies for radiolabeling and require a more customized approach. [(11)C]Carbon dioxide itself, [(11)C]carbon monoxide, [(11)C]cyanide, and [(11)C]phosgene represent alternative reactants to enable (11)C-carbonylation. Methodologies developed for preparation of (11)C-carbonyl groups have had a tremendous impact on the development of novel PET tracers and provided key tools for clinical research. (11)C-Carbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates and ureas now account for a substantial number of important imaging agents that have seen translation to higher species and clinical research of previously inaccessible targets, which is a testament to the creativity, utility and practicality of the underlying radiochemistry.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
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