Journal article Open Access

(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Rotstein, Benjamin H; Liang, Steven H; Placzek, Michael S; Hooker, Jakob M; Gee, Antony D; Dollé, Frédéric; Wilson, Alan A; Vasdev, Neil


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{
  "DOI": "10.1039/c6cs00310a", 
  "container_title": "Chem Soc Rev.", 
  "title": "(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.", 
  "issued": {
    "date-parts": [
      [
        2016, 
        6, 
        8
      ]
    ]
  }, 
  "abstract": "<p>The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for in vivo positron emission tomography (PET) imaging. Carbon-11 is most often incorporated into small molecules by methylation of alcohol, thiol, amine or carboxylic acid precursors using [(11)C]methyl iodide or [(11)C]methyl triflate (generated from [(11)C]carbon dioxide or [(11)C]methane). Consequently, small molecules that lack an easily substituted (11)C-methyl group are often considered to have non-obvious strategies for radiolabeling and require a more customized approach. [(11)C]Carbon dioxide itself, [(11)C]carbon monoxide, [(11)C]cyanide, and [(11)C]phosgene represent alternative reactants to enable (11)C-carbonylation. Methodologies developed for preparation of (11)C-carbonyl groups have had a tremendous impact on the development of novel PET tracers and provided key tools for clinical research. (11)C-Carbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates and ureas now account for a substantial number of important imaging agents that have seen translation to higher species and clinical research of previously inaccessible targets, which is a testament to the creativity, utility and practicality of the underlying radiochemistry.</p>", 
  "author": [
    {
      "family": "Rotstein, Benjamin H"
    }, 
    {
      "family": "Liang, Steven H"
    }, 
    {
      "family": "Placzek, Michael S"
    }, 
    {
      "family": "Hooker, Jakob M"
    }, 
    {
      "family": "Gee, Antony D"
    }, 
    {
      "family": "Doll\u00e9, Fr\u00e9d\u00e9ric"
    }, 
    {
      "family": "Wilson, Alan A"
    }, 
    {
      "family": "Vasdev, Neil"
    }
  ], 
  "page": "4708-26", 
  "volume": "45", 
  "type": "article-journal", 
  "issue": "17", 
  "id": "167921"
}
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