Blomster, Linda V
Strøbæk, Dorte
Christophersen, Palle
2016-03-01
<p>A research group at Saniona A/S has established a method for studying functional ion channel expression and<br>
activity in human microglia, the macrophages of the brain, isolated from epilepsy patients. Various ion channels<br>
on microglia cells are thought to promote or dampen inflammation in the brain, and inhibiting or facilitating<br>
these ion channels by pharmacological means could serve as a novel handle to treat inflammatory diseases.<br>
Through an extensive collaboration between Saniona A/S, the Neurobiology Research Unit at the Copenhagen<br>
University Hospital (Rigshospitalet) and the EU consortium INMiND (HEALTH-F2-2011-278850), we have<br>
been able to study the functional expression of several ion channels in microglia derived from adult human CNS<br>
tissue. The new findings that these channels are in fact functionally expressed in human microglia is of crucial<br>
importance in order to enhance successful translation of previous findings in animal experiments to humans.</p>
https://doi.org/10.5281/zenodo.167449
oai:zenodo.org:167449
Zenodo
http://www.biokemi.org/biozoom/issues/541/articles/2497
https://zenodo.org/communities/eu
https://doi.org/
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Detection of pro-inflammatory ion channel activity in human microglia, the brain macrophages.
info:eu-repo/semantics/other