Other Open Access

Detection of pro-inflammatory ion channel activity in human microglia, the brain macrophages.

Blomster, Linda V; Strøbæk, Dorte; Christophersen, Palle

A research group at Saniona A/S has established a method for studying functional ion channel expression and
activity in human microglia, the macrophages of the brain, isolated from epilepsy patients. Various ion channels
on microglia cells are thought to promote or dampen inflammation in the brain, and inhibiting or facilitating
these ion channels by pharmacological means could serve as a novel handle to treat inflammatory diseases.
Through an extensive collaboration between Saniona A/S, the Neurobiology Research Unit at the Copenhagen
University Hospital (Rigshospitalet) and the EU consortium INMiND (HEALTH-F2-2011-278850), we have
been able to study the functional expression of several ion channels in microglia derived from adult human CNS
tissue. The new findings that these channels are in fact functionally expressed in human microglia is of crucial
importance in order to enhance successful translation of previous findings in animal experiments to humans.

Files (109.8 kB)
Name Size
Blomster_BioZoom_2016_P28.pdf
md5:59efe18a9c4e6570bd62566d2a86bb87
109.8 kB Download
18
8
views
downloads
All versions This version
Views 1818
Downloads 88
Data volume 878.7 kB878.7 kB
Unique views 1818
Unique downloads 88

Share

Cite as