Journal article Open Access

Truncated and modified amyloid-beta species

Kummer, Markus P; Heneka, Michael T


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <controlfield tag="005">20200120154902.0</controlfield>
  <controlfield tag="001">16477</controlfield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Department of Neurology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE), Holbeinstrasse 15, 53117 Bonn, Germany.</subfield>
    <subfield code="a">Heneka, Michael T</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">862178</subfield>
    <subfield code="z">md5:c9569da59a12f3f373b47fc746ea102b</subfield>
    <subfield code="u">https://zenodo.org/record/16477/files/Kummer_AlzResTher_2014-P21.pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2014-05-26</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="p">user-ecfunded</subfield>
    <subfield code="p">user-inmind</subfield>
    <subfield code="o">oai:zenodo.org:16477</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="c">28</subfield>
    <subfield code="n">3</subfield>
    <subfield code="p">Alzheimers Res Ther. </subfield>
    <subfield code="v">6</subfield>
    <subfield code="y">2014</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Department of Neurology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany</subfield>
    <subfield code="a">Kummer, Markus P</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Truncated and modified amyloid-beta species</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-inmind</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-ecfunded</subfield>
  </datafield>
  <datafield tag="536" ind1=" " ind2=" ">
    <subfield code="c">278850</subfield>
    <subfield code="a">Imaging of Neuroinflammation in Neurodegenerative Diseases</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Alzheimer&amp;rsquo; s disease pathology is closely connected to the processing of the amyloid precursor protein (APP)&amp;nbsp;resulting in the formation of a variety of amyloid-beta (A&amp;beta; ) peptides. They are found as insoluble aggregates in&amp;nbsp;senile plaques, the histopathological hallmark of the disease. These peptides are also found in soluble, mostly&amp;nbsp;monomeric and dimeric, forms in the interstitial and cerebrospinal fluid. Due to the combination of several&amp;nbsp;enzymatic activities during APP processing, A&amp;beta;&amp;nbsp; peptides exist in multiple isoforms possessing different N-termini&amp;nbsp;and C-termini. These peptides include, to a certain extent, part of the juxtamembrane and transmembrane domain&amp;nbsp;of APP. Besides differences in size, post-translational modifications of A&amp;beta; &amp;ndash;&amp;nbsp; including oxidation, phosphorylation,&amp;nbsp;nitration, racemization, isomerization, pyroglutamylation, and glycosylation &amp;ndash;&amp;nbsp; generate a plethora of peptides with&amp;nbsp;different physiological and pathological properties that may modulate disease progression.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1186/alzrt258</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
</record>
18
33
views
downloads
Views 18
Downloads 33
Data volume 28.5 MB
Unique views 18
Unique downloads 33

Share

Cite as