Research of free radical and tissue energy supply processes on rats subjected to concurrent Tetrachlormethane and adrenaline impact after Mexidol administration

Aleksevych K. O., Fira L. S., Hrymalyuk O. I., Shtroblya A. L. Research of free radical and tissue energy supply processes on rats subjected to concurrent Tetrachlormethane and adrenaline impact after Mexidol administration. Journal of Education, Health and Sport. 2015;5(3):269-278. ISSN 2391-8306. DOI: 10.5281/zenodo.16439

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http://dx.doi.org/10.5281/zenodo.16439

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015.

UDC 599.32+615.9.]-092.4

RESEARCH OF FREE RADICAL AND TISSUE ENERGY SUPPLY PROCESSES ON RATS SUBJECTED TO CONCURRENT TETRACHLORMETHANE AND ADRENALINE IMPACT

AFTER MEXIDOL ADMINISTRATION

Aleksevych K. O.¹, Fira L. S.¹, Hrymalyuk O. I.¹, Shtroblya A. L.²

¹State Higher Educational Institution I.Ya. Horbachevsky Ternopil State Medical University, Ministry of Public Health, Ukraine

²State Higher Educational Institution Yzhhorod National University, Ukraine

Summary

Experiments on rats subjected to simultaneous impact of tetrachlormethane and increased adrenaline doses, revealed activated protein oxidative modification and lipoperoxidation. This caused suppression of tissue energy supply that is confirmed by decreased cytochrome oxidase and succinate dehydrogenase. The detected disorders were found to induce cardiocyte cytolysis, indicated by increased blood serum kreatine phosphokinase and lactate dehydrogenase activity alongside with its decrease in rats’ myocardium after the impact. Mexidol, used as an antioxidant, revealed positive influence on free radical oxidation processes as well as on the    normalization of myocardial bioenergetics.

Key words: tetrachlormethane, adrenaline, protein oxidative modification, lipoperoxidation, energy supply, Mexidol.