Journal article Open Access

Energy metabolism and fertility: a balance preserved for female health.

Della Torre, Sara; Benedusi, Valeria; Fontana, Roberta; Maggi, Adriana


DataCite XML Export

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://zenodo.org/record/16378</identifier>
  <creators>
    <creator>
      <creatorName>Della Torre, Sara</creatorName>
      <givenName>Sara</givenName>
      <familyName>Della Torre</familyName>
      <affiliation>Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy and Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133, Milan, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Benedusi, Valeria</creatorName>
      <givenName>Valeria</givenName>
      <familyName>Benedusi</familyName>
      <affiliation>Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy and Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133, Milan, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Fontana, Roberta</creatorName>
      <givenName>Roberta</givenName>
      <familyName>Fontana</familyName>
      <affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133, Milan, Italy and Italian Institute of Technology, 16163, Genova, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Maggi, Adriana</creatorName>
      <givenName>Adriana</givenName>
      <familyName>Maggi</familyName>
      <affiliation>Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133, Milan, Italy</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Energy metabolism and fertility: a balance preserved for female health.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-10-22</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/16378</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/nrendo.2013.203</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;In female animals, energy metabolism and fertility are tightly connected, and reciprocally regulated. However, the relative contributions of metabolic and reproductive pathways have changed over the course of evolution. In oviparous animals, metabolic factors take precedence over fertility, enabling egg production to be inhibited in a nutritionally poor environment. By contrast, in placental mammals, the opposite occurs: the need to feed a developing embryo and neonate forces metabolic pathways to adapt to these reproductive needs. This physiological necessity explains why in female mammals alterations of gonadal activity, including age-dependent cessation of ovarian functions, are associated with a disruption of metabolic homeostasis and consequent inflammatory reactions that trigger the onset of metabolic, cardiovascular, skeletal and neural pathologies. This Review discusses how metabolic homeostasis and reproductive functions interact to optimize female fertility and explains the pathogenic mechanisms underlying the disordered energy metabolism associated with human ovarian dysfunction owing to menopause, polycystic ovary syndrome and Turner syndrome. Finally, this article highlights how hormone replacement therapy might aid the restoration of metabolic homeostasis in women with ovarian dysfunction.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
19
38
views
downloads
Views 19
Downloads 38
Data volume 230.9 MB
Unique views 18
Unique downloads 36

Share

Cite as