Low Prevalence of Botulinum Toxin-A Adverse Effects: Good Safety Pro fi le or Underreporting?

Introduction: The incidence of botulinum toxin type A (BoNT-A) injections related adverse effects (AE) is relatively high in literature. Many of injections are carried out yearly in our Physical and Rehabilitation Medicine (PRM) unit, however only 4 adverse effects have been reported since 2010. 

The aim of this single-center prospective observational study was to determine the reasons to explain the large difference in the prevalence of AE reported in the literature and in our PRM unit, and to take measures to improve AE reporting.