Report Open Access
Höfer, Thomas; Weiser, Anne; Westerhoff, Hans; Mone, Martijn; Martins dos Santos, Vitor; Fitzmaurice, Will; Omholt, Stig; Vik, Jon Olav
This document identifies showcases illustrating the impact of modelling on biological discovery and the added-value of integrated theoretical-experimental research. It illustrates the impact of modelling through existing showcases by providing examples of existing modelling methodologies where they have led to a quantum increase in understanding of biology or medicine. There are also examples how experimental data have driven the development of new modelling approaches capable of delivering the required methodology. It illustrates outstanding, representative, examples of the added value of integrated theoretical-experimental research programmes and documents how modelling will have to guide the development of a mature phenomics discipline.