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Tuberculosis evolution and treatment outcome in drug addicted patients

Lesnic, Evelina; Cotelea, Eugen

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    "description": "<p><strong>Background: </strong>Drug injection is considered an important issue for the public health of the Republic of Moldova. In the RM the intravenous drug users&nbsp;(IVDU) are the key population for HIV infection, B and C hepatitis, TB and sexual transmitted diseases. The aim of the study was to assess the tuberculosis&nbsp;evolution and treatment outcome in intravenous drug addicted patients.</p>\n\n<p><strong>Material and methods: </strong>A retrospective selective, descriptive study targeting socioeconomic, demographic, economic and epidemiological peculiarities,&nbsp;case-management, diagnosis of radiological aspects and microbiological characteristics of 233 patients with pulmonary tuberculosis registered in Chisinau&nbsp;city from 2012 to 2016 among them 48 IVDU was performed. The results were compared with a sample of 34 IVDU.</p>\n\n<p><strong>Results:</strong> Men were predisposed for drug addiction and the age is younger in addicts with tuberculosis. Socioeconomic vulnerability is extended in the&nbsp;selected groups; however, the poverty deepness was more important in addicted patients with tuberculosis. Close contact with a sick patient predominated&nbsp;in addicts with tuberculosis, but nobody assessed the contact in addicts without tuberculosis. Associated diseases predominated in addicts with or without&nbsp;tuberculosis, more frequently were: HIV infected individuals, viral hepatitis and neurological disorders.</p>\n\n<p><strong>Conclusions:</strong> Risk factors for tuberculosis in drug addicts were: unemployment and associated lack of health insurance, patient&rsquo;s homeless state, middle&nbsp;adulthood and the immune suppressive condition &ndash; HIV infection. Major disease-related characteristic in IVDU patients was the presence of severe&nbsp;destructive forms of tuberculosis and &quot;loss to follow-up&quot; as outcome.</p>", 
    "language": "eng", 
    "title": "Tuberculosis evolution and treatment outcome in drug addicted patients", 
    "license": {
      "id": "CC-BY-4.0"
    "journal": {
      "volume": "61(3)", 
      "pages": "15-23", 
      "title": "Moldovan Medical Journal"
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    "keywords": [
      "drug use", 
      "risk factors"
    "publication_date": "2018-10-15", 
    "creators": [
        "affiliation": "Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova", 
        "name": "Lesnic, Evelina"
        "affiliation": "Republican Narcologic Dispensary, Chisinau, the Republic of Moldova", 
        "name": "Cotelea, Eugen"
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