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Tuberculosis evolution and treatment outcome in drug addicted patients

Lesnic, Evelina; Cotelea, Eugen

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  <identifier identifierType="DOI">10.5281/zenodo.1456877</identifier>
      <creatorName>Lesnic, Evelina</creatorName>
      <affiliation>Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova</affiliation>
      <creatorName>Cotelea, Eugen</creatorName>
      <affiliation>Republican Narcologic Dispensary, Chisinau, the Republic of Moldova</affiliation>
    <title>Tuberculosis evolution and treatment outcome in drug addicted patients</title>
    <subject>drug use</subject>
    <subject>risk factors</subject>
    <date dateType="Issued">2018-10-15</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
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    <rights rightsURI="">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Drug injection is considered an important issue for the public health of the Republic of Moldova. In the RM the intravenous drug users&amp;nbsp;(IVDU) are the key population for HIV infection, B and C hepatitis, TB and sexual transmitted diseases. The aim of the study was to assess the tuberculosis&amp;nbsp;evolution and treatment outcome in intravenous drug addicted patients.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;A retrospective selective, descriptive study targeting socioeconomic, demographic, economic and epidemiological peculiarities,&amp;nbsp;case-management, diagnosis of radiological aspects and microbiological characteristics of 233 patients with pulmonary tuberculosis registered in Chisinau&amp;nbsp;city from 2012 to 2016 among them 48 IVDU was performed. The results were compared with a sample of 34 IVDU.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; Men were predisposed for drug addiction and the age is younger in addicts with tuberculosis. Socioeconomic vulnerability is extended in the&amp;nbsp;selected groups; however, the poverty deepness was more important in addicted patients with tuberculosis. Close contact with a sick patient predominated&amp;nbsp;in addicts with tuberculosis, but nobody assessed the contact in addicts without tuberculosis. Associated diseases predominated in addicts with or without&amp;nbsp;tuberculosis, more frequently were: HIV infected individuals, viral hepatitis and neurological disorders.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; Risk factors for tuberculosis in drug addicts were: unemployment and associated lack of health insurance, patient&amp;rsquo;s homeless state, middle&amp;nbsp;adulthood and the immune suppressive condition &amp;ndash; HIV infection. Major disease-related characteristic in IVDU patients was the presence of severe&amp;nbsp;destructive forms of tuberculosis and &amp;quot;loss to follow-up&amp;quot; as outcome.&lt;/p&gt;</description>
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