PECULIARITIES OF EXCRETORY RENAL FUNCTION IN THE EARLY PERIOD OF ALLOXAN-INDUCED EXPERIMENTAL DIABETES

Boychuk T. M., Olenovych O. A., Gozhenko A. I. PECULIARITIES OF EXCRETORY RENAL FUNCTION IN THE EARLY PERIOD OF ALLOXAN-INDUCED EXPERIMENTAL DIABETES. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2018;3(80):102-109. ISSN 0049-6804.

DOI http://dx.doi.org/10.5281/zenodo.1450849

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УДК 616.61-008.6-07:616.379-008.64

PECULIARITIES OF EXCRETORY RENAL FUNCTION IN THE EARLY PERIOD OF ALLOXAN-INDUCED EXPERIMENTAL DIABETES

T. M. Boychuk1, O. A. Olenovych1, A. I. Gozhenko2

1Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine

2State Enterprise «Ukrainian Scientific Research Institute of Transport Medicine of Ministry of Health of Ukraine», Odesa, Ukraine

Address for correspondence: olenovych.olga@bsmu.edu.ua.

Summary. Boychuk T. M., Olenovych O. A., Gozhenko A. I. PECULIARITIES OF EXCRETORY RENAL FUNCTION IN THE EARLY PERIOD OF ALLOXAN-INDUCED EXPERIMENTAL DIABETES. The article presents data concerning the peculiarities of excretory renal function on 11th day after the administration of diabetogenic dose of alloxan (160 mg/kg) to white non-linear matured male rats. It is established, that hyperdynamically-hyperperfusing type of renal function on 11th day after the administration of diabetogenic substance results from the mobilization of adaptive, reserve renal mechanisms regulating the adaptation of the kidneys to the systemic and local effects of hyperglycemia. The character and dynamics of disorders of the excretory renal function evidences mainly the functional origin of renal disorders on the 11th day of experimental diabetes in the absence of significant structural changes in the tubular apparatus of the kidneys.

Key words: experimental diabetes mellitus, alloxan, diabetic nephropathy, excretory renal function.