Dataset Open Access

Drug Indications Extracted from FAERS

Stupp, Gregory S; Su, Andrew I

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    <subfield code="a">&lt;p&gt;This dataset contains drug indications extracted from the&amp;nbsp;FDA Adverse Event Reporting System (&lt;a href=""&gt;FAERS&lt;/a&gt;).&lt;/p&gt;

&lt;p&gt;Source code here:&amp;nbsp;&lt;a href=""&gt;;/a&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Method Outline&lt;/strong&gt;&lt;/p&gt;

	&lt;li&gt;Data files are extracted from zip files, parsed from csvs, and imported into a MySQL database (see&amp;nbsp;;/li&gt;
	&lt;li&gt;Duplicate records are then de-duplicated by taking only the most recent version for each case ID (see&amp;nbsp;;/li&gt;
	&lt;li&gt;Indications are normalized by matching to UMLS terms by string matching. Cross-references to Human Phenotype Ontology are pulled from UMLS and xrefs to Monarch Disease Ontology (MONDO) are pulled from MONDO using the UMLS xrefs. (See&amp;nbsp;;/li&gt;
	&lt;li&gt;Drugs names are normalized first by applying a few simple string cleaning operations (strip, fix slashes and periods). Then they are attempted to be matched to rxnorm by exact string matching. Those that don&amp;#39;t match are run against rxnorm&amp;#39;s &lt;a href=""&gt;approximate matching service&lt;/a&gt;, and are accepted if the score is higher than&amp;nbsp;67/100. The matched rxnorm CUIs are then mapped to the their Ingredient level rxnorm ID. (See&amp;nbsp;;/li&gt;
	&lt;li&gt;Indications are then retrieved for each drug ingredient and filtered to require a minimum of 20 individual occurances. (See&amp;nbsp;;/li&gt;
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