Dataset Open Access

Developing a Tryptophan Fluorescence Assay for Screening Ligands against USP5 Zf-UBD

Mann, Mandeep; Harding, Rachel; Edwards, Aled; Arrowsmith, Cheryl; Schapira, Matthieu


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  <identifier identifierType="DOI">10.5281/zenodo.1424041</identifier>
  <creators>
    <creator>
      <creatorName>Mann, Mandeep</creatorName>
      <givenName>Mandeep</givenName>
      <familyName>Mann</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-8252-6107</nameIdentifier>
      <affiliation>University of Toronto, Structural Genomics Consortium</affiliation>
    </creator>
    <creator>
      <creatorName>Harding, Rachel</creatorName>
      <givenName>Rachel</givenName>
      <familyName>Harding</familyName>
      <affiliation>University of Toronto, Structural Genomics Consortium</affiliation>
    </creator>
    <creator>
      <creatorName>Edwards, Aled</creatorName>
      <givenName>Aled</givenName>
      <familyName>Edwards</familyName>
      <affiliation>University of Toronto, Structural Genomics Consortium</affiliation>
    </creator>
    <creator>
      <creatorName>Arrowsmith, Cheryl</creatorName>
      <givenName>Cheryl</givenName>
      <familyName>Arrowsmith</familyName>
      <affiliation>University of Toronto, Structural Genomics Consortium</affiliation>
    </creator>
    <creator>
      <creatorName>Schapira, Matthieu</creatorName>
      <givenName>Matthieu</givenName>
      <familyName>Schapira</familyName>
      <affiliation>University of Toronto, Structural Genomics Consortium</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Developing a Tryptophan Fluorescence Assay for Screening Ligands against USP5 Zf-UBD</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2018</publicationYear>
  <subjects>
    <subject>zinc finger</subject>
    <subject>USP5</subject>
    <subject>Trp fluorescence</subject>
    <subject>assay development</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2018-09-21</date>
  </dates>
  <resourceType resourceTypeGeneral="Dataset"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1424041</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.1424040</relatedIdentifier>
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    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/sgc-opennotebook</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Development of a fluorescence based assay by measuring changes in UV tryptophan fluorescence of USP5 zinc finger ubiquitin binding domain (Zf-UBD) with addition of ligands&lt;/p&gt;</description>
    <description descriptionType="Other">Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.</description>
  </descriptions>
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