Journal article Open Access

Teratogenic Effects of Ethanol Leaf Extract of Dryopteris filix-mas L. Schott

Earnest Oghenesuvwe Erhirhie; Oluchi Nzubechukwu Ezemokwe; Emmanuel Emeka Ilodigwe

This study evaluated the teratogenic profile of ethanol leaf extract of Dryopteris filix-mas. Thirty-two (32) female virgin albino mice were grouped into control and treatment groups (250, 500 and 1000 mg/kg of extract). Oestrus female mice were mated with males and pregnant female mice were administered the extract from the 6th until the 15th day of pregnancy. Morphological parameters as well as histopathologies of the femur, liver, kidneys, lungs and heart of pups in treatment and control groups were carried out. Administration of 250, 500, 1000 mg/kg of the leaf extract did not cause significant alteration (p>0.05) in morphological parameters in pups when compared with control group. There was no alteration in histo-architecture of the lungs, femurs, liver, heart and kidneys but there was poor mineralization in metaphysis of pups femur in high dose of the extract when compared to control group.

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