10.2174/1381612820666140613120212
https://zenodo.org/records/12773
oai:zenodo.org:12773
Ory, Dieter
Dieter
Ory
Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium
Celeb, Sofie
Sofie
Celeb
Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium
Verbruggen, Alfons
Alfons
Verbruggen
Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium
Bormans, Guy
Guy
Bormans
Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium
PET Radioligands for in Vivo Visualization of Neuroinflammation.
Zenodo
2014
neuroinflammation
positron emission tomography
2014-06-13
https://zenodo.org/communities/inmind
https://zenodo.org/communities/eu
Creative Commons Attribution 4.0 International
Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders.
The microglia which make up the innate immune system of the central nervous system are key cellular mediators of neuroinflammatory processes. In normal condition they exert a protective function, providing tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. Upon neuronal injury or infection, they become overactivated, thereby releasing neurotoxic substances, amplifying neuroinflammation leading to neurodegeneration. Positron emission tomography (PET) provides a sensitive non-invasive imaging technique to study and quantify receptor and enzyme expression. A radiolabeled tracer for a protein (over)expressed in neuroinflammation and more specifically for the overactivated microglia would be useful as a diagnostic tool in the follow-up of neuroinflammation progression and to study the efficacy of anti-inflammatory therapy over time. In this manuscript, an overview of potential PET tracer targets unregulated during neuroinflammation is provided together with the current radiotracers used to image these targets. In addition, lead structures to develop radiotracers for new targets are suggested.
European Commission
10.13039/501100000780
278850
Imaging of Neuroinflammation in Neurodegenerative Diseases