Ιntegrated External and Internal Exposure Modelling Platform (INTEGRA)
- 1. Aristotle University of Thessaloniki, Department of Chemical Engineering, Environmental Engineering Laboratory, 54124 Thessaloniki, Greece 2 Centre for Research and Technology Hellas, Chemical Process and Energy Resources Institute, Natural and Renewable Resource Exploitation Laboratory, 57001 Thessaloniki, Greece 3 Institute for Advanced Study (IUSS), Environmental Health Engineering, Piazza della Vittoria 15, 27100 Pavia, Italy
- 2. 1 Aristotle University of Thessaloniki, Department of Chemical Engineering, Environmental Engineering Laboratory, 54124 Thessaloniki, Greece 2 Centre for Research and Technology Hellas, Chemical Process and Energy Resources Institute, Natural and Renewable Resource Exploitation Laboratory, 57001 Thessaloniki, Greece
- 3. 1 Aristotle University of Thessaloniki, Department of Chemical Engineering, Environmental Engineering Laboratory, 54124 Thessaloniki, Greece
- 4. 1 Aristotle University of Thessaloniki, Department of Chemical Engineering, Environmental Engineering Laboratory, 54124 Thessaloniki, Greece 3 Institute for Advanced Study (IUSS), Environmental Health Engineering, Piazza della Vittoria 15, 27100 Pavia, Italy
Description
The current study aims at a comprehensive risk characterization of bisphenol A (BPA)
supported by an integrated exposure modelling framework that comprises far field and near
field exposure modelling coupled to a dynamic lifetime PBTK model. Exposure analysis was
done on European data of BPA food residues and human biomonitoring (HBM). The latter
were further assimilated through an advanced exposure reconstruction modelling framework
to estimate the corresponding external and internal systemic dose of BPA and its
metabolites. Special attention was paid on the assessment of exposure to BPA during critical
developmental stages such as gestation by modelling the mother-fetus toxicokinetic
interaction. Our findings showed that current exposure levels in Europe are below the
temporary Tolerable Daily Intake (t-TDI) of 4 μg/kg_bw/d proposed by the European Food
Safety Authority. Taking into account age-dependent bioavailability differences, internal
exposure of premature neonates hosted in intensive care units was reckoned close to the
biologically effective dose (BED) resulting from translating the EFSA temporary total daily
intake (t-TDI) into equivalent internal dose. Use of the ToxCast21 Biological Pathway Altering
Dose (BPAD) as an alternative internal exposure reference value, resulted in increased
margins of safety compared to the conventional exposure/risk characterization scheme
Files
Files
(832.9 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:c69be0a03d889ba635455d5a1f7fbcc3
|
832.9 kB | Download |