Journal article Open Access

Comprehensive analysis of citrate effects during plateletpheresis in normal donors

Bolan, Charles D.; Greer, Sarah E.; Cecco, Stacey A.; Oblitas, Jaime M.; Rehak, Nadja N.; Leitman, Susan F.


Citation Style Language JSON Export

{
  "DOI": "10.1046/j.1537-2995.2001.41091165.x", 
  "author": [
    {
      "family": "Bolan, Charles D."
    }, 
    {
      "family": "Greer, Sarah E."
    }, 
    {
      "family": "Cecco, Stacey A."
    }, 
    {
      "family": "Oblitas, Jaime M."
    }, 
    {
      "family": "Rehak, Nadja N."
    }, 
    {
      "family": "Leitman, Susan F."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2001, 
        9, 
        1
      ]
    ]
  }, 
  "abstract": "BACKGROUND: Although plateletpheresis procedures are generally well tolerated, the clinical and metabolic consequences associated with rapid infusion of up to 10 g of citrate are underappreciated, and a comprehensive description of these events is not available.\n\nSTUDY DESIGN AND METHODS: Clinical and laboratory changes were studied in seven healthy donors undergoing three 90\u2010minute plateletpheresis procedures each, at continuous, fixed citrate infusion rates of 1.1, 1.4, and 1.6 mg per kg per minute.\n\nRESULTS: Serum citrate levels increased markedly with increasing citrate infusion rates and did not achieve a stable plateau. As citrate infusion rates increased, the total volume processed and platelet yields also increased, but donor symptoms became more severe. Ionized calcium (iCa) and ionized magnesium (iMg) concentrations decreased markedly, by 33 and 39 percent below baseline, respectively, at a citrate rate of 1.6 mg per kg per minute. Intact parathyroid hormone levels were higher at 30 minutes than at later time points, despite progressive decreases in iCa and iMg. Urine citrate, calcium, magnesium, sodium, and potassium concentrations and urine pH values increased markedly during all procedures.\n\nCONCLUSION: Marked, progressive increases in serum citrate levels occur during plateletpheresis, accompanied by symptomatic decreases in iCa and iMg, with significantly increased renal excretion of calcium, magnesium, and citrate.", 
  "title": "Comprehensive analysis of citrate effects during plateletpheresis in normal donors", 
  "type": "article-journal", 
  "id": "1236510"
}
175
84
views
downloads
Views 175
Downloads 84
Data volume 19.7 MB
Unique views 175
Unique downloads 84

Share

Cite as