Journal article Open Access

Allopurinol pharmacogenetics: assessment of potential clinical usefulness

Zineh, Issam; Mummaneni, Padmaja; Lyndly, Jenna; Amur, Shashi; La Grenade, Lois A.; Chang, Stephen H.; Rogers, Hobart; Pacanowski, Michael A.


Dublin Core Export

<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Zineh, Issam</dc:creator>
  <dc:creator>Mummaneni, Padmaja</dc:creator>
  <dc:creator>Lyndly, Jenna</dc:creator>
  <dc:creator>Amur, Shashi</dc:creator>
  <dc:creator>La Grenade, Lois A.</dc:creator>
  <dc:creator>Chang, Stephen H.</dc:creator>
  <dc:creator>Rogers, Hobart</dc:creator>
  <dc:creator>Pacanowski, Michael A.</dc:creator>
  <dc:date>2011-12-01</dc:date>
  <dc:description>Use of pharmacogenetics to inform treatment decisions remains a priority for clinicians, patients and public health agencies. We previously developed a framework for systematically assessing whether pharmacogenetic test information would likely bring value to clinical decision-making and enjoy practical uptake. We applied this tool to allopurinol to determine potential usefulness of HLA genetic information in assessing risk for allopurinol-induced severe cutaneous adverse reactions. We quantified allopurinol use data and the magnitude of adverse event signals using US FDA databases, reviewed reported cases of allopurinol-associated severe cutaneous adverse reactions to assess whether clinical subtypes of patients could be identified, performed pooled analyses of associations between HLA variation and allopurinol-induced severe cutaneous adverse reactions and described considerations in clinical implementation of allopurinol pharmacogenetics.</dc:description>
  <dc:identifier>https://zenodo.org/record/1236437</dc:identifier>
  <dc:identifier>10.2217/pgs.11.131</dc:identifier>
  <dc:identifier>oai:zenodo.org:1236437</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/publicdomain/zero/1.0/legalcode</dc:rights>
  <dc:title>Allopurinol pharmacogenetics: assessment of potential clinical usefulness</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
256
176
views
downloads
Views 256
Downloads 176
Data volume 114.2 MB
Unique views 246
Unique downloads 169

Share

Cite as