Journal article Open Access

Allopurinol pharmacogenetics: assessment of potential clinical usefulness

Zineh, Issam; Mummaneni, Padmaja; Lyndly, Jenna; Amur, Shashi; La Grenade, Lois A.; Chang, Stephen H.; Rogers, Hobart; Pacanowski, Michael A.


JSON-LD (schema.org) Export

{
  "description": "Use of pharmacogenetics to inform treatment decisions remains a priority for clinicians, patients and public health agencies. We previously developed a framework for systematically assessing whether pharmacogenetic test information would likely bring value to clinical decision-making and enjoy practical uptake. We applied this tool to allopurinol to determine potential usefulness of HLA genetic information in assessing risk for allopurinol-induced severe cutaneous adverse reactions. We quantified allopurinol use data and the magnitude of adverse event signals using US FDA databases, reviewed reported cases of allopurinol-associated severe cutaneous adverse reactions to assess whether clinical subtypes of patients could be identified, performed pooled analyses of associations between HLA variation and allopurinol-induced severe cutaneous adverse reactions and described considerations in clinical implementation of allopurinol pharmacogenetics.", 
  "license": "https://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Zineh, Issam"
    }, 
    {
      "@type": "Person", 
      "name": "Mummaneni, Padmaja"
    }, 
    {
      "@type": "Person", 
      "name": "Lyndly, Jenna"
    }, 
    {
      "@type": "Person", 
      "name": "Amur, Shashi"
    }, 
    {
      "@type": "Person", 
      "name": "La Grenade, Lois A."
    }, 
    {
      "@type": "Person", 
      "name": "Chang, Stephen H."
    }, 
    {
      "@type": "Person", 
      "name": "Rogers, Hobart"
    }, 
    {
      "@type": "Person", 
      "name": "Pacanowski, Michael A."
    }
  ], 
  "headline": "Allopurinol pharmacogenetics: assessment of potential clinical usefulness", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2011-12-01", 
  "url": "https://zenodo.org/record/1236437", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.2217/pgs.11.131", 
  "@id": "https://doi.org/10.2217/pgs.11.131", 
  "@type": "ScholarlyArticle", 
  "name": "Allopurinol pharmacogenetics: assessment of potential clinical usefulness"
}
256
176
views
downloads
Views 256
Downloads 176
Data volume 114.2 MB
Unique views 246
Unique downloads 169

Share

Cite as