Journal article Open Access

Structure and Function of Natural-Killer-Cell Receptors

Sun, Peter D.


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  <dc:creator>Sun, Peter D.</dc:creator>
  <dc:date>2003-02-01</dc:date>
  <dc:description>The function of natural-killer (NK) cells is modulated by the balance between a number of activating and inhibitory receptors. Killer immunoglobulinlike receptors (KIRs) are mostly inhibitory receptors. They play a critical role in recognizing self-class-I major histocompatibility complex (MHC) molecules and thus protect healthy host cells from NK-targeted lysis. In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected cells through either direct ligand engagement or antibody-dependent cellular cytotoxicity (ADCC). Through structural studies of members of these distinct receptor families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ligand recognition.</dc:description>
  <dc:identifier>https://zenodo.org/record/1236303</dc:identifier>
  <dc:identifier>10.1385/ir:27:2-3:539</dc:identifier>
  <dc:identifier>oai:zenodo.org:1236303</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/publicdomain/zero/1.0/legalcode</dc:rights>
  <dc:title>Structure and Function of Natural-Killer-Cell Receptors</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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