Journal article Open Access

Structure and Function of Natural-Killer-Cell Receptors

Sun, Peter D.


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{
  "description": "The function of natural-killer (NK) cells is modulated by the balance between a number of activating and inhibitory receptors. Killer immunoglobulinlike receptors (KIRs) are mostly inhibitory receptors. They play a critical role in recognizing self-class-I major histocompatibility complex (MHC) molecules and thus protect healthy host cells from NK-targeted lysis. In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected cells through either direct ligand engagement or antibody-dependent cellular cytotoxicity (ADCC). Through structural studies of members of these distinct receptor families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ligand recognition.", 
  "license": "https://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Sun, Peter D."
    }
  ], 
  "headline": "Structure and Function of Natural-Killer-Cell Receptors", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2003-02-01", 
  "url": "https://zenodo.org/record/1236303", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1385/ir:27:2-3:539", 
  "@id": "https://doi.org/10.1385/ir:27:2-3:539", 
  "@type": "ScholarlyArticle", 
  "name": "Structure and Function of Natural-Killer-Cell Receptors"
}
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