Journal article Open Access

Structure and Function of Natural-Killer-Cell Receptors

Sun, Peter D.


JSON Export

{
  "files": [
    {
      "links": {
        "self": "https://zenodo.org/api/files/c8f8b721-447d-461c-8f16-2da39b5ffa5c/article.pdf"
      }, 
      "checksum": "md5:538ac125f1d6838b7f8de361b0ab7531", 
      "bucket": "c8f8b721-447d-461c-8f16-2da39b5ffa5c", 
      "key": "article.pdf", 
      "type": "pdf", 
      "size": 313474
    }
  ], 
  "owners": [
    13380
  ], 
  "doi": "10.1385/ir:27:2-3:539", 
  "stats": {
    "version_unique_downloads": 156.0, 
    "unique_views": 290.0, 
    "views": 294.0, 
    "version_views": 294.0, 
    "unique_downloads": 156.0, 
    "version_unique_views": 290.0, 
    "volume": 50155840.0, 
    "version_downloads": 160.0, 
    "downloads": 160.0, 
    "version_volume": 50155840.0
  }, 
  "links": {
    "doi": "https://doi.org/10.1385/ir:27:2-3:539", 
    "latest_html": "https://zenodo.org/record/1236303", 
    "bucket": "https://zenodo.org/api/files/c8f8b721-447d-461c-8f16-2da39b5ffa5c", 
    "badge": "https://zenodo.org/badge/doi/10.1385/ir%3A27%3A2-3%3A539.svg", 
    "html": "https://zenodo.org/record/1236303", 
    "latest": "https://zenodo.org/api/records/1236303"
  }, 
  "created": "2018-04-28T18:27:36.383224+00:00", 
  "updated": "2020-01-20T17:33:02.574896+00:00", 
  "conceptrecid": "1236302", 
  "revision": 6, 
  "id": 1236303, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.1385/ir:27:2-3:539", 
    "description": "The function of natural-killer (NK) cells is modulated by the balance between a number of activating and inhibitory receptors. Killer immunoglobulinlike receptors (KIRs) are mostly inhibitory receptors. They play a critical role in recognizing self-class-I major histocompatibility complex (MHC) molecules and thus protect healthy host cells from NK-targeted lysis. In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected cells through either direct ligand engagement or antibody-dependent cellular cytotoxicity (ADCC). Through structural studies of members of these distinct receptor families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ligand recognition.", 
    "license": {
      "id": "CC0-1.0"
    }, 
    "title": "Structure and Function of Natural-Killer-Cell Receptors", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "1236302"
          }, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "1236303"
          }
        }
      ]
    }, 
    "publication_date": "2003-02-01", 
    "creators": [
      {
        "name": "Sun, Peter D."
      }
    ], 
    "access_right": "open", 
    "resource_type": {
      "subtype": "article", 
      "type": "publication", 
      "title": "Journal article"
    }
  }
}
294
160
views
downloads
Views 294
Downloads 160
Data volume 50.2 MB
Unique views 290
Unique downloads 156

Share

Cite as