Journal article Open Access
Wang, M. G.; Yi, H.; Guerini, D. G.; Klee, C. B.; McBride, O. W.
<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> <dc:creator>Wang, M. G.</dc:creator> <dc:creator>Yi, H.</dc:creator> <dc:creator>Guerini, D. G.</dc:creator> <dc:creator>Klee, C. B.</dc:creator> <dc:creator>McBride, O. W.</dc:creator> <dc:date>1996-01-01</dc:date> <dc:description>Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in signal transduction. The enzyme is a heterodimer of a 58–59 kDa calmodulin-binding catalytic subunit (calcineurin A) and a small (i.e. 19 kDa) Ca2+-binding regulatory subunit (calcineurin B). The highly conserved calcineurin B is encoded by a single gene in all tissues except testes, whereas there are three isoforms of calcineurin A (α, β and γ) encoded by genes on three different chromosomes. This enzyme can play a critical role in transcriptional regulation and growth control in T lymphocytes by a mechanism believed to involve dephosphorylation of the nuclear factor NF-AT which is essential for transcription of the interleukin-2 gene. To better evaluate the potential role of the calcineurin genes in human genetic disorders, we have studied their chromosome locations. Calcineurin B (PPP3R1) is located on human chromosome 2p16→p15 and calcineurin Aβ (PPP3CB, previous gene symbol CALNB) is present on 10q21→q22. We confirm the localization of calcineurin Aα (PPP3CA, previous gene symbol CALNA) to chromosome 4 without regional localization.</dc:description> <dc:identifier>https://zenodo.org/record/1235418</dc:identifier> <dc:identifier>10.1159/000134198</dc:identifier> <dc:identifier>oai:zenodo.org:1235418</dc:identifier> <dc:rights>info:eu-repo/semantics/openAccess</dc:rights> <dc:rights>https://creativecommons.org/publicdomain/zero/1.0/legalcode</dc:rights> <dc:title>Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> <dc:type>publication-article</dc:type> </oai_dc:dc>