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Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively

Wang, M. G.; Yi, H.; Guerini, D. G.; Klee, C. B.; McBride, O. W.


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{
  "description": "Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in signal transduction. The enzyme is a heterodimer of a 58\u201359 kDa calmodulin-binding catalytic subunit (calcineurin A) and a small (i.e. 19 kDa) Ca2+-binding regulatory subunit (calcineurin B). The highly conserved calcineurin B is encoded by a single gene in all tissues except testes, whereas there are three isoforms of calcineurin A (\u03b1, \u03b2 and \u03b3) encoded by genes on three different chromosomes. This enzyme can play a critical role in transcriptional regulation and growth control in T lymphocytes by a mechanism believed to involve dephosphorylation of the nuclear factor NF-AT which is essential for transcription of the interleukin-2 gene. To better evaluate the potential role of the calcineurin genes in human genetic disorders, we have studied their chromosome locations. Calcineurin B (PPP3R1) is located on human chromosome 2p16\u2192p15 and calcineurin A\u03b2 (PPP3CB, previous gene symbol CALNB) is present on 10q21\u2192q22. We confirm the localization of calcineurin A\u03b1 (PPP3CA, previous gene symbol CALNA) to chromosome 4 without regional localization.", 
  "license": "https://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Wang, M. G."
    }, 
    {
      "@type": "Person", 
      "name": "Yi, H."
    }, 
    {
      "@type": "Person", 
      "name": "Guerini, D. G."
    }, 
    {
      "@type": "Person", 
      "name": "Klee, C. B."
    }, 
    {
      "@type": "Person", 
      "name": "McBride, O. W."
    }
  ], 
  "headline": "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21\u2192q22 and 2p16\u2192p15 respectively", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "1996-01-01", 
  "url": "https://zenodo.org/record/1235418", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1159/000134198", 
  "@id": "https://doi.org/10.1159/000134198", 
  "@type": "ScholarlyArticle", 
  "name": "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21\u2192q22 and 2p16\u2192p15 respectively"
}
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