January 1, 1996 Journal article Open Access

Wang, M. G.; Yi, H.; Guerini, D. G.; Klee, C. B.; McBride, O. W.

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  <identifier identifierType="URL">https://zenodo.org/record/1235418</identifier>
  <creators>
    <creator>
      <creatorName>Wang, M. G.</creatorName>
      <givenName>M. G.</givenName>
      <familyName>Wang</familyName>
    </creator>
    <creator>
      <creatorName>Yi, H.</creatorName>
      <givenName>H.</givenName>
      <familyName>Yi</familyName>
    </creator>
    <creator>
      <creatorName>Guerini, D. G.</creatorName>
      <givenName>D. G.</givenName>
      <familyName>Guerini</familyName>
    </creator>
    <creator>
      <creatorName>Klee, C. B.</creatorName>
      <givenName>C. B.</givenName>
      <familyName>Klee</familyName>
    </creator>
    <creator>
      <creatorName>McBride, O. W.</creatorName>
      <givenName>O. W.</givenName>
      <familyName>McBride</familyName>
    </creator>
  </creators>
  <titles>
    <title>Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>1996</publicationYear>
  <dates>
    <date dateType="Issued">1996-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1235418</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1159/000134198</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/publicdomain/zero/1.0/legalcode">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in signal transduction. The enzyme is a heterodimer of a 58–59 kDa calmodulin-binding catalytic subunit (calcineurin A) and a small (i.e. 19 kDa) Ca2+-binding regulatory subunit (calcineurin B). The highly conserved calcineurin B is encoded by a single gene in all tissues except testes, whereas there are three isoforms of calcineurin A (α, β and γ) encoded by genes on three different chromosomes. This enzyme can play a critical role in transcriptional regulation and growth control in T lymphocytes by a mechanism believed to involve dephosphorylation of the nuclear factor NF-AT which is essential for transcription of the interleukin-2 gene. To better evaluate the potential role of the calcineurin genes in human genetic disorders, we have studied their chromosome locations. Calcineurin B (PPP3R1) is located on human chromosome 2p16→p15 and calcineurin Aβ (PPP3CB, previous gene symbol CALNB) is present on 10q21→q22. We confirm the localization of calcineurin Aα (PPP3CA, previous gene symbol CALNA) to chromosome 4 without regional localization.</description>
  </descriptions>
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