1235307
doi
10.1159/000017333
oai:zenodo.org:1235307
Clark, Rebekah R.
Koehler-Stec, Ellen
Li, Kang
Smith, Carolyn B.
Davies, Peter
Maher, Fran
Simpson, Ian A.
Glucose Transporter Expression in Brain: Relationship to Cerebral Glucose Utilization
Vannucci, Susan J.
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
Glucose is the principle energy source for mammalian brain. Delivery of glucose from the blood to the brain requires its transport across the endothelial cells of the blood-brain barrier and across the plasma membranes of neurons and glia, which is mediated by the facilitative glucose transporter proteins. The two primary glucose transporter isoforms which function in cerebral glucose metabolism are GLUT1 and GLUT3. GLUT1 is the primary transporter in the blood-brain barrier, choroid plexus, ependyma, and glia; GLUT3 is the neuronal glucose transporter. The levels of expression of both transporters are regulated in concert with metabolic demand and regional rates of cerebral glucose utilization. We present several experimental paradigms in which alterations in energetic demand and/or substrate supply affect glucose transporter expression. These include normal cerebral development in the rat, Alzheimer's disease, neuronal differentiation in vitro, and dehydration in the rat.
Zenodo
1998-01-01
info:eu-repo/semantics/article
1235306
1579541568.123753
2303790
md5:d4d2d493184bfca6502aea3c998f3073
https://zenodo.org/records/1235307/files/article.pdf
public