Journal article Open Access

the Multifaceted Regulation of Interleukin-15 Expression and the Role of This Cytokine in Nk Cell Differentiation and Host Response to Intracellular Pathogens 1

Waldmann, T. A.; Tagaya, Y.


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{
  "DOI": "10.1146/annurev.immunol.17.1.19", 
  "author": [
    {
      "family": "Waldmann, T. A."
    }, 
    {
      "family": "Tagaya, Y."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        1999, 
        4, 
        1
      ]
    ]
  }, 
  "abstract": "Interleukin-15 (IL-15) is a 14- to 15-kDa member of the 4 \u03b1-helix bundle family of cytokines. IL-15 expression is controlled at the levels of transcription, translation, and intracellular trafficking. In particular, IL-15 protein is posttranscriptionally regulated by multiple controlling elements that impede translation, including 12 upstream AUGs of the 5\u2032 UTR, 2 unusual signal peptides, and the C-terminus of the mature protein. IL-15 uses two distinct receptor and signaling pathways. In T and NK cells the IL-15 receptor includes IL-2/15R\u03b2 and \u03b3c, subunits, which are shared with IL-2, and an IL-15-specific receptor subunit, IL-15R\u03b1. Mast cells respond to IL-15 with a receptor system that does not share elements with the IL-2 receptor but uses a novel 60- to 65-kDa IL-15RX subunit. In mast cells IL-15 signaling involves Jak2/STAT5 activation rather than the Jak1/Jak3 and STAT5/STAT3 system used in activated T cells. In addition to its other functional activities in immune and nonimmune cells, IL-15 plays a pivotal role in the development, survival, and function of NK cells. Abnormalities of IL-15 expression have been described in patients with rheumatoid arthritis or inflammatory bowel disease and in diseases associated with the retroviruses HIV and HTLV-I. New approaches directed toward IL-15, its receptor, or its signaling pathway may be of value in the therapy of these disorders.", 
  "title": "the Multifaceted Regulation of Interleukin-15 Expression and the Role of This Cytokine in Nk Cell Differentiation and Host Response to Intracellular Pathogens 1", 
  "type": "article-journal", 
  "id": "1234987"
}
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