Journal article Open Access

Mini ReviewHuman Interferons Alpha, Beta and Omega

Bekisz, Joseph; Schmeisser, Hana; Hernandez, Jessica; Goldman, Neil D.; Zoon, Kathryn C.

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<oai_dc:dc xmlns:dc="" xmlns:oai_dc="" xmlns:xsi="" xsi:schemaLocation="">
  <dc:creator>Bekisz, Joseph</dc:creator>
  <dc:creator>Schmeisser, Hana</dc:creator>
  <dc:creator>Hernandez, Jessica</dc:creator>
  <dc:creator>Goldman, Neil D.</dc:creator>
  <dc:creator>Zoon, Kathryn C.</dc:creator>
  <dc:description>Type I interferons (IFNs), IFN-α, IFN-β, IFN-ω, IFN-δ and IFN-τ are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-α/β with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.</dc:description>
  <dc:title>Mini ReviewHuman Interferons Alpha, Beta and Omega</dc:title>
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