Journal article Open Access

Mini ReviewHuman Interferons Alpha, Beta and Omega

Bekisz, Joseph; Schmeisser, Hana; Hernandez, Jessica; Goldman, Neil D.; Zoon, Kathryn C.


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    "description": "Type I interferons (IFNs), IFN-\u03b1, IFN-\u03b2, IFN-\u03c9, IFN-\u03b4 and IFN-\u03c4 are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-\u03b1/\u03b2 with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.", 
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