Journal article Open Access

Mini ReviewHuman Interferons Alpha, Beta and Omega

Bekisz, Joseph; Schmeisser, Hana; Hernandez, Jessica; Goldman, Neil D.; Zoon, Kathryn C.


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{
  "DOI": "10.1080/08977190400000833", 
  "author": [
    {
      "family": "Bekisz, Joseph"
    }, 
    {
      "family": "Schmeisser, Hana"
    }, 
    {
      "family": "Hernandez, Jessica"
    }, 
    {
      "family": "Goldman, Neil D."
    }, 
    {
      "family": "Zoon, Kathryn C."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2004, 
        12, 
        1
      ]
    ]
  }, 
  "abstract": "Type I interferons (IFNs), IFN-\u03b1, IFN-\u03b2, IFN-\u03c9, IFN-\u03b4 and IFN-\u03c4 are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-\u03b1/\u03b2 with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.", 
  "title": "Mini ReviewHuman Interferons Alpha, Beta and Omega", 
  "type": "article-journal", 
  "id": "1234455"
}
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