1233419
doi
10.1016/j.urolonc.2008.07.014
oai:zenodo.org:1233419
Kb, Jacobs
Jacobs, Kevin B.
Yeager, Meredith
Kraft, Peter
Wacholder, Sholom
Orr, Nick
Yu, Kai
Chatterjee, Nilanjan
Welch, Robert
Hutchinson, Amy
Crenshaw, Andrew
Cancel Tassin, Geraldine
Staats, Brian J.
Wang, Zhaoming
Gonzales Bosquet, J.
Fang, Jun
Deng, Xiang
Si, Berndt
Ee, Calle
Berndt, Sonja I.
Hs, Feigelson
Calle, Eugenia E.
Mj, Thun
Feigelson, Heather Spencer
Rodriquez, C.
Thun, Michael J.
Rodriguez, Carmen
Virtamo, Jarmo
Fr, Schumacher
Weinstein, Stephanie
Wc, Willett
Giovannucci, Edward
Schumacher, Fredrick R.
Cussenot, Olivier
Willett, Walter C.
Gl, Andriole
Valeri, Antoine
Ed, Crawford
Albanes, Demetrius
Andriole, Gerald L.
Ds, Gerhard
Tucker, Margaret
Crawford, E. David
Jf, Fraumeni
Gerhard, Daniela S.
Rb, Hayes
Hoover, Robert
Fraumeni, Joseph F.
Dj, Hunter
Sj, Chanock
Hayes, Richard B.
Bj, Staals
Hunter, David J.
Brooks, James
Chanock, Stephen J.
Multiple loci identified in a genome-wide association study of prostate cancer
Thomas, Gilles
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial prospective study—by testing 26,958 SNPs in four independent studies (total of 3,941 cases and 3,964 controls). In the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2 on 17q); P < 10−10). In addition, loci on chromosomes 7, 10 (two loci) and 11 were highly significant (between P < 7.31 × 10−13 and P < 2.14 × 10−6). Loci on chromosome 10 include MSMB, which encodes β-microseminoprotein, a primary constituent of semen and a proposed prostate cancer biomarker, and CTBP2, a gene with antiapoptotic activity; the locus on chromosome 7 is at JAZF1, a transcriptional repressor that is fused by chromosome translocation to SUZ12 in endometrial cancer. Of the nine loci that showed highly suggestive associations (P < 2.5 × 10−5), four best fit a recessive model and included candidate susceptibility genes: CPNE3, IL16 and CDH13. Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals.
Zenodo
2008-01-01
info:eu-repo/semantics/article
1233418
1579541989.364665
392893
md5:7f4bc84af77f3c33521e962abba58c2a
https://zenodo.org/records/1233419/files/article.pdf
public