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Linkage Between Sexual Orientation and Chromosome Xq28 in Males but not in Females

Hu, Stella; Pattatucci, Angela M. L.; Patterson, Chavis; Li, Lin; Fulker, David W.; Cherny, Stacey S.; Kruglyak, Leonid; Hamer, Dean H.

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  <identifier identifierType="URL"></identifier>
      <creatorName>Hu, Stella</creatorName>
      <creatorName>Pattatucci, Angela M. L.</creatorName>
      <givenName>Angela M. L.</givenName>
      <creatorName>Patterson, Chavis</creatorName>
      <creatorName>Li, Lin</creatorName>
      <creatorName>Fulker, David W.</creatorName>
      <givenName>David W.</givenName>
      <creatorName>Cherny, Stacey S.</creatorName>
      <givenName>Stacey S.</givenName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="">0000-0002-0269-3352</nameIdentifier>
      <creatorName>Kruglyak, Leonid</creatorName>
      <creatorName>Hamer, Dean H.</creatorName>
      <givenName>Dean H.</givenName>
    <title>Linkage Between Sexual Orientation and Chromosome Xq28 in Males but not in Females</title>
    <date dateType="Issued">1995-11-01</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/ng1195-248</relatedIdentifier>
    <rights rightsURI="">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex–linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.</description>
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