Journal article Open Access

Lymphocyte activation by HIV-1 envelope glycoprotein

Kornfeld, Hardy; Cruikshank, William W.; Pyle, Stephen W.; Berman, Jeffrey S.; Center, David M.


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{
  "description": "Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro1\u20133. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-14,5 and binds the viral envelope glycoprotein (gp120)6,7. In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor8\u201310, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.", 
  "license": "http://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Kornfeld, Hardy"
    }, 
    {
      "@type": "Person", 
      "name": "Cruikshank, William W."
    }, 
    {
      "@type": "Person", 
      "name": "Pyle, Stephen W."
    }, 
    {
      "@type": "Person", 
      "name": "Berman, Jeffrey S."
    }, 
    {
      "@type": "Person", 
      "name": "Center, David M."
    }
  ], 
  "url": "https://zenodo.org/record/1233075", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "1988-09-29", 
  "headline": "Lymphocyte activation by HIV-1 envelope glycoprotein", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1038/335445a0", 
  "@id": "https://doi.org/10.1038/335445a0", 
  "@type": "ScholarlyArticle", 
  "name": "Lymphocyte activation by HIV-1 envelope glycoprotein"
}
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