10.1038/335445a0
https://zenodo.org/records/1233075
oai:zenodo.org:1233075
Kornfeld, Hardy
Hardy
Kornfeld
Cruikshank, William W.
William W.
Cruikshank
Pyle, Stephen W.
Stephen W.
Pyle
Berman, Jeffrey S.
Jeffrey S.
Berman
Center, David M.
David M.
Center
Lymphocyte activation by HIV-1 envelope glycoprotein
Zenodo
1988
1988-09-29
Creative Commons Zero v1.0 Universal
Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro1–3. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-14,5 and binds the viral envelope glycoprotein (gp120)6,7. In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor8–10, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.