Journal article Open Access

Lymphocyte activation by HIV-1 envelope glycoprotein

Kornfeld, Hardy; Cruikshank, William W.; Pyle, Stephen W.; Berman, Jeffrey S.; Center, David M.

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  <identifier identifierType="URL"></identifier>
      <creatorName>Kornfeld, Hardy</creatorName>
      <creatorName>Cruikshank, William W.</creatorName>
      <givenName>William W.</givenName>
      <creatorName>Pyle, Stephen W.</creatorName>
      <givenName>Stephen W.</givenName>
      <creatorName>Berman, Jeffrey S.</creatorName>
      <givenName>Jeffrey S.</givenName>
      <creatorName>Center, David M.</creatorName>
      <givenName>David M.</givenName>
    <title>Lymphocyte activation by HIV-1 envelope glycoprotein</title>
    <date dateType="Issued">1988-09-29</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/335445a0</relatedIdentifier>
    <rights rightsURI="">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro1–3. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-14,5 and binds the viral envelope glycoprotein (gp120)6,7. In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor8–10, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.</description>
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