Journal article Open Access

Lymphocyte activation by HIV-1 envelope glycoprotein

Kornfeld, Hardy; Cruikshank, William W.; Pyle, Stephen W.; Berman, Jeffrey S.; Center, David M.


Citation Style Language JSON Export

{
  "DOI": "10.1038/335445a0", 
  "author": [
    {
      "family": "Kornfeld, Hardy"
    }, 
    {
      "family": "Cruikshank, William W."
    }, 
    {
      "family": "Pyle, Stephen W."
    }, 
    {
      "family": "Berman, Jeffrey S."
    }, 
    {
      "family": "Center, David M."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        1988, 
        9, 
        29
      ]
    ]
  }, 
  "abstract": "Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro1\u20133. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-14,5 and binds the viral envelope glycoprotein (gp120)6,7. In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor8\u201310, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.", 
  "title": "Lymphocyte activation by HIV-1 envelope glycoprotein", 
  "type": "article-journal", 
  "id": "1233075"
}
32
10
views
downloads
Views 32
Downloads 10
Data volume 5.5 MB
Unique views 32
Unique downloads 10

Share

Cite as