1232872
doi
10.1007/s11899-012-0132-3
oai:zenodo.org:1232872
Roschewski, Mark
Wilson, Wyndham H.
Lymphomatoid Granulomatosis and Other Epstein-Barr Virus Associated Lymphoproliferative Processes
Dunleavy, Kieron
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
We now recognize that the Epstein-Barr virus (EBV), which is a member of the γ- herpesvirus family, plays a pivotal role in the development of several lymphomas and lymphoproliferative disorders that include B-cell, T-cell and NK-cell processes. While over recent years, EBV associated lymphomas that arise in patients with known defects in cellular immunity are relatively well characterized, these diseases are becoming increasingly recognized in patients without overt immunodeficiency. Improved understanding of the biology of these lymphomas including elucidating the role that EBV plays in their pathogenesis has paved the way for improved therapies targeted at critical signaling pathways as well as the development of novel cellular therapies. In this review, we focus on recent progress that has been made in the biology and treatment of the rare EBV-associated disorder lymphomatoid granulomatosis (LYG) and also discuss other EBV-associated processes that occur in both immunocompetent and immunocompromised hosts.
Zenodo
2012-07-20
info:eu-repo/semantics/article
1232871
1579530241.71748
234936
md5:62b218f34a700ed563766b6600471f0b
https://zenodo.org/records/1232872/files/article.pdf
public