Journal article Open Access

A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation

Hamer, D. H.; Hu, S.; Magnuson, V. L.; Hu, N.; Pattatucci, A. M. L.

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<oai_dc:dc xmlns:dc="" xmlns:oai_dc="" xmlns:xsi="" xsi:schemaLocation="">
  <dc:creator>Hamer, D. H.</dc:creator>
  <dc:creator>Hu, S.</dc:creator>
  <dc:creator>Magnuson, V. L.</dc:creator>
  <dc:creator>Hu, N.</dc:creator>
  <dc:creator>Pattatucci, A. M. L.</dc:creator>
  <dc:description>The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10(-5), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.</dc:description>
  <dc:title>A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation</dc:title>
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