August 1, 1993 Journal article Open Access

Hamer, D. H.; Hu, S.; Magnuson, V. L.; Hu, N.; Pattatucci, A. M. L.

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{
  "description": "The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10(-5), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.", 
  "license": "https://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Hamer, D. H."
    }, 
    {
      "@type": "Person", 
      "name": "Hu, S."
    }, 
    {
      "@type": "Person", 
      "name": "Magnuson, V. L."
    }, 
    {
      "@type": "Person", 
      "name": "Hu, N."
    }, 
    {
      "@type": "Person", 
      "name": "Pattatucci, A. M. L."
    }
  ], 
  "headline": "A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "1993-08-01", 
  "url": "https://zenodo.org/record/1231257", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1126/science.8332896", 
  "@id": "https://doi.org/10.1126/science.8332896", 
  "@type": "ScholarlyArticle", 
  "name": "A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation"
}